A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing.
Angiogenesis
L1CAM
NOVA2
Ovarian Cancer
atermative splicing
cancer biology
cell biology
human
mouse
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
04 03 2019
04 03 2019
Historique:
received:
12
12
2018
accepted:
08
02
2019
entrez:
5
3
2019
pubmed:
5
3
2019
medline:
20
3
2020
Statut:
epublish
Résumé
The biological players involved in angiogenesis are only partially defined. Here, we report that endothelial cells (ECs) express a novel isoform of the cell-surface adhesion molecule L1CAM, termed L1-ΔTM. The splicing factor NOVA2, which binds directly to
Identifiants
pubmed: 30829570
doi: 10.7554/eLife.44305
pii: 44305
pmc: PMC6398979
doi:
pii:
Substances chimiques
Angiogenic Proteins
0
L1CAM protein, human
0
NOVA2 protein, human
0
Nerve Tissue Proteins
0
Neural Cell Adhesion Molecule L1
0
Neuro-Oncological Ventral Antigen
0
Protein Isoforms
0
RNA-Binding Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : IG-17395
Pays : International
Organisme : Worldwide Cancer Research
ID : AICR 10-0091
Pays : United Kingdom
Organisme : Horizon 2020 Framework Programme
ID : ERC-StG-LS2-637591
Pays : International
Organisme : Ministerio de Economía y Competitividad
ID : BFU2017-89201-P
Pays : International
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : IG-14622
Pays : International
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : IG-18853
Pays : International
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : IG-18683
Pays : International
Informations de copyright
© 2019, Angiolini et al.
Déclaration de conflit d'intérêts
EB, MG, MC, FF, PP, ML, CB, DP, AD, CG, GJ, CL, GB, SF, MM, MI, CG, RG, DN, DG No competing interests declared, JM, JS Affiliated with Gene Tools, LLC. Funding bodies had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript. ED Reviewing editor, eLife, CG Consultant for Gene-Tools, LLC. Funding bodies had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.
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