HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells From Donors With Type 1 Diabetes.
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
20
06
2018
accepted:
25
02
2019
pubmed:
6
3
2019
medline:
19
11
2019
entrez:
6
3
2019
Statut:
ppublish
Résumé
Type 1 diabetes studies consistently generate data showing islet β-cell dysfunction and T cell-mediated anti-β-cell-specific autoimmunity. To explore the pathogenesis, we interrogated the β-cell transcriptomes from donors with and without type 1 diabetes using both bulk-sorted and single β-cells. Consistent with immunohistological studies, β-cells from donors with type 1 diabetes displayed increased Class I transcripts and associated mRNA species. These β-cells also expressed mRNA for Class II and Class II antigen presentation pathway components, but lacked the macrophage marker CD68. Immunohistological study of three independent cohorts of donors with recent-onset type 1 diabetes showed Class II protein and its transcriptional regulator Class II MHC
Identifiants
pubmed: 30833470
pii: db18-0686
doi: 10.2337/db18-0686
pmc: PMC6477908
doi:
Substances chimiques
Histocompatibility Antigens Class II
0
Insulin
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
988-1001Subventions
Organisme : NIDDK NIH HHS
ID : P60 DK020593
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK104211
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK108120
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK116284
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK112232
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020593
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK105837
Pays : United States
Organisme : NIDDK NIH HHS
ID : R24 DK106755
Pays : United States
Informations de copyright
© 2019 by the American Diabetes Association.
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