Synergistic activity of colistin with azidothymidine against colistin-resistant Klebsiella pneumoniae clinical isolates collected from inpatients in Greek hospitals.
Azidothymidine
Colistin
Enterobacteriaceae
Gram-negative
Repurposing
Synergism
Journal
International journal of antimicrobial agents
ISSN: 1872-7913
Titre abrégé: Int J Antimicrob Agents
Pays: Netherlands
ID NLM: 9111860
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
26
10
2018
revised:
08
02
2019
accepted:
26
02
2019
pubmed:
6
3
2019
medline:
3
9
2019
entrez:
6
3
2019
Statut:
ppublish
Résumé
New antibiotics are urgently needed to treat multi-drug resistant infections; however, production of novel antibiotics is diminishing. Synergistic combination drug therapy to enhance the activity of available antibiotics may improve management of patients with resistant infections. Colistin-resistant Klebsiella pneumoniae isolates were collected from inpatients in 10 Greek hospitals and used to study combination activity of colistin plus azidothymidine. Combination activity was evaluated with the sum of fractional inhibitory concentrations (ΣFIC) using the mini checkerboard broth microdilution method. A hundred individual strains were tested. Synergistic activity was noted in 79% (79/100) of isolates and additive activity in the remaining 21% (21/100). ΣFIC Colistin with azidothymidine exhibited promising synergistic activity against colistin-resistant Klebsiella pneumoniae isolates warranting further investigation of the combination.
Sections du résumé
BACKGROUND
BACKGROUND
New antibiotics are urgently needed to treat multi-drug resistant infections; however, production of novel antibiotics is diminishing. Synergistic combination drug therapy to enhance the activity of available antibiotics may improve management of patients with resistant infections.
METHODS
METHODS
Colistin-resistant Klebsiella pneumoniae isolates were collected from inpatients in 10 Greek hospitals and used to study combination activity of colistin plus azidothymidine. Combination activity was evaluated with the sum of fractional inhibitory concentrations (ΣFIC) using the mini checkerboard broth microdilution method.
RESULTS
RESULTS
A hundred individual strains were tested. Synergistic activity was noted in 79% (79/100) of isolates and additive activity in the remaining 21% (21/100). ΣFIC
CONCLUSION
CONCLUSIONS
Colistin with azidothymidine exhibited promising synergistic activity against colistin-resistant Klebsiella pneumoniae isolates warranting further investigation of the combination.
Identifiants
pubmed: 30836109
pii: S0924-8579(19)30051-2
doi: 10.1016/j.ijantimicag.2019.02.021
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Zidovudine
4B9XT59T7S
Colistin
Z67X93HJG1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
855-858Informations de copyright
Copyright © 2019 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.