[Neurobiology of opioid dependence].
Neurobiologie der Opioidabhängigkeit.
Genetic predisposition, opioid addiction
Locus caeruleus
Pharmacokinetics, opioids
Psychosocial factors
Reward, dopaminergic
Journal
Der Anaesthesist
ISSN: 1432-055X
Titre abrégé: Anaesthesist
Pays: Germany
ID NLM: 0370525
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
entrez:
7
3
2019
pubmed:
7
3
2019
medline:
12
6
2020
Statut:
ppublish
Résumé
Opioid dependence is a chronic mental disease with multifactorial etiology. The neurobiological theory of addiction focuses on the manipulation of the dopaminergic reward system as a basic property of substances with addictive potential including opioids. With regular opioid intake, the manipulation of the reward system results in a cognitive bias towards drug-related stimuli. In addition, opioids inhibit the locus caeruleus, resulting in symptoms of sympathetic rebound during opioid detoxification. The pharmacokinetics of opioids also influence the risk of addiction. These biological factors are independent of the legal status of the individual opioid. Genetics also significantly influence the etiology. However, the assignment of this genetic influence is difficult because not only basic biological functions, but also personality traits and mental illnesses are genetically determined.
Identifiants
pubmed: 30840108
doi: 10.1007/s00101-019-0557-3
pii: 10.1007/s00101-019-0557-3
doi:
Substances chimiques
Analgesics, Opioid
0
Types de publication
Journal Article
Langues
ger
Sous-ensembles de citation
IM
Pagination
179-190Références
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