Dietary coconut oil ameliorates skin contact hypersensitivity through mead acid production in mice.
8,11,14-Eicosatrienoic Acid
/ analogs & derivatives
Actins
/ metabolism
Animals
Biomarkers
Capillary Permeability
Chemotaxis
/ immunology
Coconut Oil
/ adverse effects
Dermatitis, Atopic
/ diagnosis
Dermatitis, Contact
/ diagnosis
Dietary Fats, Unsaturated
/ adverse effects
Disease Models, Animal
Female
Immunohistochemistry
Immunophenotyping
Leukotriene B4
/ biosynthesis
Lipid Metabolism
Mice
Neutrophils
/ immunology
Skin
/ immunology
LTB4
coconut oil
mead acid
neutrophils
skin inflammation
Journal
Allergy
ISSN: 1398-9995
Titre abrégé: Allergy
Pays: Denmark
ID NLM: 7804028
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
22
06
2018
revised:
19
12
2018
accepted:
13
01
2019
pubmed:
8
3
2019
medline:
30
7
2020
entrez:
8
3
2019
Statut:
ppublish
Résumé
Coconut oil is used as a dietary oil worldwide, and its healthy effects are recognized by the fact that coconut oil is easy to digest, helps in weight management, increases healthy cholesterol, and provides instant energy. Although topical application of coconut oil is known to reduce skin infection and inflammation, whether dietary coconut oil has any role in decreasing skin inflammation is unknown. In this study, we showed the impact of dietary coconut oil in allergic skin inflammation by using a mouse model of contact hypersensitivity (CHS). Mice maintained on coconut oil showed amelioration of skin inflammation and increased levels of cis-5, 8, 11-eicosatrienoic acid (mead acid) in serum. Intraperitoneal injection of mead acid inhibited CHS and reduced the number of neutrophils infiltrating to the skin. Detailed mechanistic studies unveiled that mead acid inhibited the directional migration of neutrophils by inhibiting the filamentous actin polymerization and leukotriene B
Substances chimiques
Actins
0
Biomarkers
0
Dietary Fats, Unsaturated
0
Leukotriene B4
1HGW4DR56D
8,11,14-Eicosatrienoic Acid
FC398RK06S
mead acid
JQS194YH3X
Coconut Oil
Q9L0O73W7L
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1522-1532Subventions
Organisme : Tokyo Biochemical Research Foundation
Pays : International
Organisme : Takeda Science Foundation
Pays : International
Informations de copyright
© 2019 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.