Association of childhood pulmonary tuberculosis with exposure to indoor air pollution: a case control study.
Adolescent
Age Factors
Air Pollutants
/ adverse effects
Air Pollution, Indoor
/ adverse effects
Case-Control Studies
Child
Child, Preschool
Cooking
/ methods
Environmental Exposure
/ adverse effects
Female
HIV Infections
/ epidemiology
Humans
Infant
Infant, Newborn
Male
Risk Factors
South Africa
/ epidemiology
Tobacco Smoke Pollution
/ adverse effects
Tuberculosis, Pulmonary
/ epidemiology
Childhood tuberculosis
Dampness
Exposure assessment
Indoor air pollution
Risk factors
Secondhand smoke
Journal
BMC public health
ISSN: 1471-2458
Titre abrégé: BMC Public Health
Pays: England
ID NLM: 100968562
Informations de publication
Date de publication:
07 Mar 2019
07 Mar 2019
Historique:
received:
25
09
2018
accepted:
27
02
2019
entrez:
9
3
2019
pubmed:
9
3
2019
medline:
7
5
2019
Statut:
epublish
Résumé
Crude measures of exposure to indicate indoor air pollution have been associated with the increased risk for acquiring tuberculosis. Our study aimed to determine an association between childhood pulmonary tuberculosis (PTB) and exposure to indoor air pollution (IAP), based on crude exposure predictors and directly sampled and modelled pollutant concentrations. In this case control study, children diagnosed with PTB were compared to children without PTB. Questionnaires about children's health; and house characteristics and activities (including household air pollution) and secondhand smoke (SHS) exposure were administered to caregivers of participants. A subset of the participants' homes was sampled for measurements of PM Of the 234 participants, 107 were cases and 127 were controls. Pollutants concentrations (μg/m Our study suggests increased risk of childhood tuberculosis disease when children are exposed to SHS, dirty cooking fuel, and dampness in their homes. Yet, HIV status, age and TB contact are the most important risk factors of childhood PTB in this population.
Sections du résumé
BACKGROUND
BACKGROUND
Crude measures of exposure to indicate indoor air pollution have been associated with the increased risk for acquiring tuberculosis. Our study aimed to determine an association between childhood pulmonary tuberculosis (PTB) and exposure to indoor air pollution (IAP), based on crude exposure predictors and directly sampled and modelled pollutant concentrations.
METHODS
METHODS
In this case control study, children diagnosed with PTB were compared to children without PTB. Questionnaires about children's health; and house characteristics and activities (including household air pollution) and secondhand smoke (SHS) exposure were administered to caregivers of participants. A subset of the participants' homes was sampled for measurements of PM
RESULTS
RESULTS
Of the 234 participants, 107 were cases and 127 were controls. Pollutants concentrations (μg/m
CONCLUSION
CONCLUSIONS
Our study suggests increased risk of childhood tuberculosis disease when children are exposed to SHS, dirty cooking fuel, and dampness in their homes. Yet, HIV status, age and TB contact are the most important risk factors of childhood PTB in this population.
Identifiants
pubmed: 30845944
doi: 10.1186/s12889-019-6604-9
pii: 10.1186/s12889-019-6604-9
pmc: PMC6407209
doi:
Substances chimiques
Air Pollutants
0
Tobacco Smoke Pollution
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
275Subventions
Organisme : FIC NIH HHS
ID : U2R TW007373
Pays : United States
Organisme : National Institutes for Health-Fogarty International (Bethesda, MD, USA) and South African TB/AIDS Research Training (SATBAT, Johannesburg, South Africa) Grant
ID : 5U2RTW00773 and 5U2RTW007373
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