A pentavalent vaccine for rainbow trout in Danish aquaculture.
Aeromonas salmonicida
Animals
Antibodies, Bacterial
/ blood
Antigens, Bacterial
/ immunology
Aquaculture
Bacterial Vaccines
/ immunology
Denmark
Fish Diseases
/ microbiology
Furunculosis
/ immunology
Oncorhynchus mykiss
/ immunology
Vaccination
/ veterinary
Vibrio
Vibrio Infections
/ prevention & control
Yersinia Infections
/ prevention & control
Yersinia ruckeri
Aeromonas salmonicida subsp. salmonicida
Aquaculture
Rainbow trout
Vaccination
Vibrio anguillarum
Yersinia ruckeri
Journal
Fish & shellfish immunology
ISSN: 1095-9947
Titre abrégé: Fish Shellfish Immunol
Pays: England
ID NLM: 9505220
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
19
12
2018
revised:
28
02
2019
accepted:
01
03
2019
pubmed:
10
3
2019
medline:
26
7
2019
entrez:
10
3
2019
Statut:
ppublish
Résumé
Mariculture in Denmark is based on production of rainbow trout grown two years in fresh water followed by one growth season in sea cages. Although the majority of rainbow trout are vaccinated against the most serious bacterial pathogens - Aeromonas salmonicida subsp. salmonicida, Vibrio anguillarum and Yersinia ruckeri, by the use of commercially available vaccines, disease outbreaks requiring treatment with antibiotics still occur. The present study tested the potential of a new experimental multicomponent vaccine that is based on local bacterial strains, isolated from rainbow trout in Danish waters, and thus custom-designed for Danish rainbow trout mariculture. The vaccination with the multicomponent vaccine resulted in protection against three relevant bacterial diseases (yersiniosis, furunculosis, vibriosis) under experimental conditions. We showed that i.p. injection of the vaccine induced specific antibody responses in trout against the different bacterial antigens and regulated expression of genes encoding SAA, C3, IL-1β, IL-6, IL-8, IgD and MHCII.
Identifiants
pubmed: 30851449
pii: S1050-4648(19)30140-8
doi: 10.1016/j.fsi.2019.03.001
pii:
doi:
Substances chimiques
Antibodies, Bacterial
0
Antigens, Bacterial
0
Bacterial Vaccines
0
Types de publication
Journal Article
Langues
eng
Pagination
344-351Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.