FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling.

Animals Cadherins / chemistry Gene Deletion Glial Cell Line-Derived Neurotrophic Factor / metabolism Glial Cell Line-Derived Neurotrophic Factor Receptors / metabolism Humans Intercellular Signaling Peptides and Proteins Kidney / abnormalities Mice Nerve Tissue Proteins / deficiency Protein Binding Proto-Oncogene Proteins c-ret / metabolism Signal Transduction Up-Regulation
CAKUT FAT4 RET Van Maldergem syndrome cadherin kidney development non-autonomous

Journal

Developmental cell
ISSN: 1878-1551
Titre abrégé: Dev Cell
Pays: United States
ID NLM: 101120028

Informations de publication

Date de publication:
25 03 2019
Historique:
received: 26 08 2018
revised: 06 12 2018
accepted: 01 02 2019
pubmed: 12 3 2019
medline: 19 9 2019
entrez: 12 3 2019
Statut: ppublish

Résumé

FAT4 mutations lead to several human diseases that disrupt the normal development of the kidney. However, the underlying mechanism remains elusive. In studying the duplex kidney phenotypes observed upon deletion of Fat4 in mice, we have uncovered an interaction between the atypical cadherin FAT4 and RET, a tyrosine kinase receptor essential for kidney development. Analysis of kidney development in Fat4

Identifiants

DOI: 10.1016/j.devcel.2019.02.004 PMID: 30853441 PMC: PMC6766079
pubmed: 30853441
pii: S1534-5807(19)30095-4
doi: 10.1016/j.devcel.2019.02.004
pmc: PMC6766079
mid: NIHMS1539240
pii:
doi:

Substances chimiques

Cadherins 0
Dchs1 protein, mouse 0
Fat4 protein, mouse 0
Fjx1 protein, mouse 0
Gfra1 protein, mouse 0
Glial Cell Line-Derived Neurotrophic Factor 0
Glial Cell Line-Derived Neurotrophic Factor Receptors 0
Intercellular Signaling Peptides and Proteins 0
Nerve Tissue Proteins 0
Proto-Oncogene Proteins c-ret EC 2.7.10.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

780-792.e4

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK082531
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

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Auteurs

Hongtao Zhang (H)

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.

Mazdak Bagherie-Lachidan (M)

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.

Caroline Badouel (C)

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada; Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, 118 Route de Narbonne, Toulouse 31062, France.

Leonie Enderle (L)

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.

Philippos Peidis (P)

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.

Rod Bremner (R)

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada; Departments of Ophthalmology and Visual Science, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada.

Satu Kuure (S)

GM-unit at Laboratory Animal Centre, HiLIFE and Medicum, University of Helsinki, Helsinki 00014, Finland.

Sanjay Jain (S)

Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Helen McNeill (H)

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: mcneillh@wustl.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › FAT4 Fine-Tunes Kidney Development by...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Cadhérines › FAT4 Fine-Tunes Kidney Development by...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Délétion de séquence › Délétion de gène › FAT4 Fine-Tunes Kidney Development by...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance nerveuse › Facteurs neurotrophiques dérivés des cellules gliales › Facteur neurotrophique dérivé des cellules gliales › FAT4 Fine-Tunes Kidney Development by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs facteur croissance nerf › Récepteurs des facteurs neurotrophiques dérivés des cellules gliales › FAT4 Fine-Tunes Kidney Development by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › FAT4 Fine-Tunes Kidney Development by...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › FAT4 Fine-Tunes Kidney Development by...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › FAT4 Fine-Tunes Kidney Development by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › FAT4 Fine-Tunes Kidney Development by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › FAT4 Fine-Tunes Kidney Development by...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › FAT4 Fine-Tunes Kidney Development by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-ret › FAT4 Fine-Tunes Kidney Development by...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › FAT4 Fine-Tunes Kidney Development by...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation positive › FAT4 Fine-Tunes Kidney Development by...