Aging and the Combined effects of ADRA2B and CB1 deletions on Affective Working Memory.
Aged
Aging
/ genetics
Emotions
/ physiology
Female
Genetic Predisposition to Disease
Genotype
Haplotypes
/ genetics
Heterozygote
Humans
Male
Memory, Short-Term
/ physiology
Mental Recall
/ physiology
Middle Aged
Polymorphism, Genetic
Receptor, Cannabinoid, CB1
/ genetics
Receptors, Adrenergic, alpha-2
/ genetics
Sequence Deletion
/ genetics
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
11 03 2019
11 03 2019
Historique:
received:
17
09
2018
accepted:
04
02
2019
entrez:
13
3
2019
pubmed:
13
3
2019
medline:
2
10
2020
Statut:
epublish
Résumé
Many studies have found that memory for affective material is better than memory for neutral information and memory for positive material compared to negative material is better in older adults. Behavioral, neurophysiological as well as single polymorphism differences have been advanced to account for these effects. Here, we aimed to examine whether the combination of two polymorphisms (ADRA2B and CB1) in older adults influences active maintenance and manipulation of emotional information in aging working memory. We examined genotype data from 207 older adults (56 double deletion carriers, 116 single deletion carriers and 35 no deletion carriers) who performed a verbal operation span-like task with positive, negative and neutral words. We found that subjects carrying both ADRA2B and CB1 variants generally remembered a higher number of words. In addition, double carriers showed positivity effects while single carriers showed more general emotional enhancement effects, especially as strings lengthened. These findings are amongst the first to suggest a haplotype account of positivity effects in older adults' memory.
Identifiants
pubmed: 30858399
doi: 10.1038/s41598-019-40108-5
pii: 10.1038/s41598-019-40108-5
pmc: PMC6411975
doi:
Substances chimiques
ADRA2B protein, human
0
Receptor, Cannabinoid, CB1
0
Receptors, Adrenergic, alpha-2
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4081Références
Memory. 2018 Feb;26(2):260-268
pubmed: 28685667
Learn Mem. 2016 Jun 17;23(7):349-58
pubmed: 27317195
J Stat Softw. 2015 Mar 20;64(7):1-30
pubmed: 27307779
Neurobiol Learn Mem. 2016 Apr;130:129-34
pubmed: 26899992
Psychol Aging. 2002 Jun;17(2):299-320
pubmed: 12061414
Nat Neurosci. 2007 Sep;10(9):1137-9
pubmed: 17660814
Addict Biol. 2008 Jun;13(2):196-212
pubmed: 18422832
Neuropsychopharmacology. 2015 May;40(6):1436-47
pubmed: 25510937
Behav Res Methods. 2014 Sep;46(3):887-903
pubmed: 24150921
BMC Med Res Methodol. 2013 Oct 23;13:129
pubmed: 24152389
Coll Antropol. 2010 Dec;34(4):1427-32
pubmed: 21874733
Clin Interv Aging. 2018 Apr 06;13:573-593
pubmed: 29670342
Psychol Aging. 2014 Mar;29(1):1-15
pubmed: 24660792
Neurobiol Learn Mem. 2014 Jul;112:222-9
pubmed: 24149058
J Pers Soc Psychol. 1988 Jun;54(6):1063-70
pubmed: 3397865
Psychol Sci. 2004 Apr;15(4):259-63
pubmed: 15043644
Neurobiol Aging. 2006 Feb;27(2):361-74
pubmed: 16399218
Trends Cogn Sci. 2005 Oct;9(10):496-502
pubmed: 16154382
Front Psychol. 2014 Nov 21;5:1331
pubmed: 25484871
Front Psychiatry. 2014 Jun 30;5:73
pubmed: 25071606
J Neurosci. 2006 Sep 13;26(37):9503-11
pubmed: 16971534
Neurosci Biobehav Rev. 2008;32(3):581-97
pubmed: 18164058
Neurobiol Learn Mem. 2014 Jul;112:30-43
pubmed: 24382324
Biostatistics. 2010 Jul;11(3):484-98
pubmed: 20350957
Brain Res. 2006 Mar 24;1079(1):86-97
pubmed: 16490183
Neurobiol Learn Mem. 2013 Jul;103:11-8
pubmed: 23583499
Neurobiol Aging. 2013 Jan;34(1):298-308
pubmed: 22743090
Neuroscience. 2012 Mar 1;204:134-44
pubmed: 21827834
Trends Cogn Sci. 2016 Mar;20(3):214-226
pubmed: 26895736
Behav Brain Res. 2017 Aug 30;333:218-224
pubmed: 28697904
Schizophr Res. 2012 Jun;138(1):99-101
pubmed: 22507636
J Neurol Sci. 2013 May 15;328(1-2):19-23
pubmed: 23499426
Psychol Rev. 1996 Jul;103(3):403-28
pubmed: 8759042
Neuropsychol Rehabil. 2013;23(3):416-28
pubmed: 23452136
Psychoneuroendocrinology. 2014 Oct;48:111-22
pubmed: 24997351
Psychol Aging. 2005 Dec;20(4):579-88
pubmed: 16420133
J Neurosci. 2015 Apr 22;35(16):6506-16
pubmed: 25904801
Annu Rev Psychol. 2016;67:213-38
pubmed: 26436717
Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19191-6
pubmed: 19826083
Vision Res. 2009 Jun;49(10):1154-65
pubmed: 18694779
Ageing Res Rev. 2016 May;27:61-66
pubmed: 27003374
Psychol Sci. 2013 Nov 1;24(11):2244-53
pubmed: 24058067