Synthesis, Characterisation and In Vitro Permeation, Dissolution and Cytotoxic Evaluation of Ruthenium(II)-Liganded Sulpiride and Amino Alcohol.

Animals Caco-2 Cells Dopamine Antagonists / chemical synthesis Humans Intestinal Absorption Propanolamines / chemistry Ruthenium Compounds / chemical synthesis Sulpiride / analogs & derivatives Swine

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
11 03 2019
Historique:
received: 04 10 2018
accepted: 07 02 2019
entrez: 13 3 2019
pubmed: 13 3 2019
medline: 25 9 2020
Statut: epublish

Résumé

Sulpiride (SPR) is a selective antagonist of central dopamine receptors but has limited clinical use due to its poor pharmacokinetics. The aim of this study was to investigate how metal ligation to SPR may improve its solubility, intestinal permeability and prolong its half-life. The synthesis and characterisation of ternary metal complexes [Ru(p -cymene)(L)(SPR)]PF

Identifiants

DOI: 10.1038/s41598-019-40538-1 PMID: 30858469 PMC: PMC6412051
pubmed: 30858469
doi: 10.1038/s41598-019-40538-1
pii: 10.1038/s41598-019-40538-1
pmc: PMC6412051
doi:

Substances chimiques

Dopamine Antagonists 0
Propanolamines 0
Ruthenium Compounds 0
Sulpiride 7MNE9M8287

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4146

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Auteurs

Gretta C M'bitsi-Ibouily (GC)

Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa.

Thashree Marimuthu (T)

Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa.
ORCID: 0000-0003-1487-5273

Pradeep Kumar (P)

Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa.

Yahya E Choonara (YE)

Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa.

Lisa C du Toit (LC)

Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa.

Priyamvada Pradeep (P)

Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa.

Girish Modi (G)

Department of Neurology, Division of Neurosciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa.

Viness Pillay (V)

Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa. viness.pillay@wits.ac.za.
ORCID: 0000-0002-8119-3347

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Synthesis, Characterisation and In Vitro...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules Caco-2 › Synthesis, Characterisation and In Vitro...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents dopaminergiques › Antagonistes de la dopamine › Synthesis, Characterisation and In Vitro...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Synthesis, Characterisation and In Vitro...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil buccodentaire et de l'appareil digestif › Phénomènes physiologiques de l'appareil digestif › Absorption gastro-intestinale › Absorption intestinale › Synthesis, Characterisation and In Vitro...
questionsmedicales.fr › Composés chimiques organiques › Amines › Aminoalcools › Propanolamines › Synthesis, Characterisation and In Vitro...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du ruthénium › Synthesis, Characterisation and In Vitro...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Benzoates › Benzamides › Sulpiride › Synthesis, Characterisation and In Vitro...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Synthesis, Characterisation and In Vitro...