GABA
Alcoholism
/ drug therapy
Allosteric Regulation
/ drug effects
Animals
Discrimination Learning
/ drug effects
Dose-Response Relationship, Drug
Ethanol
/ administration & dosage
GABA-A Receptor Agonists
/ administration & dosage
GABA-A Receptor Antagonists
/ administration & dosage
Macaca mulatta
Male
Protein Subunits
/ agonists
Receptors, GABA-A
/ physiology
Self Administration
Alpha
Drug Discrimination
Ethanol
GABAA
Self-Administration
Journal
Alcoholism, clinical and experimental research
ISSN: 1530-0277
Titre abrégé: Alcohol Clin Exp Res
Pays: England
ID NLM: 7707242
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
18
09
2018
accepted:
26
02
2019
pubmed:
13
3
2019
medline:
3
7
2020
entrez:
13
3
2019
Statut:
ppublish
Résumé
Previous studies have investigated α1GABA In discrimination studies, subjects were trained to discriminate EtOH (2 g/kg, intragastrically) from water under a fixed-ratio (FR) schedule of food delivery. In oral self-administration studies, subjects were trained to self-administer EtOH (2% w/v) or sucrose (0.3 to 1% w/v) under an FR schedule of solution availability. In discrimination studies, functionally selective PAMs at α2GABA Our results confirm prior findings regarding the respective roles of α1GABA
Sections du résumé
BACKGROUND
Previous studies have investigated α1GABA
METHODS
In discrimination studies, subjects were trained to discriminate EtOH (2 g/kg, intragastrically) from water under a fixed-ratio (FR) schedule of food delivery. In oral self-administration studies, subjects were trained to self-administer EtOH (2% w/v) or sucrose (0.3 to 1% w/v) under an FR schedule of solution availability.
RESULTS
In discrimination studies, functionally selective PAMs at α2GABA
CONCLUSIONS
Our results confirm prior findings regarding the respective roles of α1GABA
Identifiants
pubmed: 30861153
doi: 10.1111/acer.14000
pmc: PMC6601614
mid: NIHMS1016785
doi:
Substances chimiques
GABA-A Receptor Agonists
0
GABA-A Receptor Antagonists
0
GABRA1 protein, human
0
GABRA2 protein, human
0
GABRA3 protein, human
0
Protein Subunits
0
Receptors, GABA-A
0
Ethanol
3K9958V90M
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
791-802Subventions
Organisme : NINDS NIH HHS
ID : R01 NS076517
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA011792
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH096463
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH046851
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA016179
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA033795
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA043204
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL118561
Pays : United States
Informations de copyright
© 2019 by the Research Society on Alcoholism.
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