Effects of deuteration on transamination and oxidation of hyperpolarized
Alanine
/ metabolism
Alanine Transaminase
/ metabolism
Amination
Animals
Carbon Isotopes
Deuterium
/ chemistry
In Vitro Techniques
L-Lactate Dehydrogenase
/ metabolism
Lactic Acid
/ metabolism
Magnetic Resonance Spectroscopy
Myocardium
/ metabolism
Oxidation-Reduction
Pyruvate Dehydrogenase Complex
/ metabolism
Pyruvic Acid
/ metabolism
Rats
Rats, Sprague-Dawley
Water
/ chemistry
Deuteration
Hyperpolarization
Isolated hearts
Isotopomer analysis
Kinetic isotope effects
Perfusions
Journal
Journal of magnetic resonance (San Diego, Calif. : 1997)
ISSN: 1096-0856
Titre abrégé: J Magn Reson
Pays: United States
ID NLM: 9707935
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
16
01
2019
revised:
01
03
2019
accepted:
03
03
2019
pubmed:
13
3
2019
medline:
2
10
2020
entrez:
13
3
2019
Statut:
ppublish
Résumé
This study was designed to determine the effects of deuteration in pyruvate on exchange reactions in alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and flux through pyruvate dehydrogenase (PDH). Although deuteration of a
Identifiants
pubmed: 30861456
pii: S1090-7807(19)30036-9
doi: 10.1016/j.jmr.2019.03.003
pmc: PMC6666394
mid: NIHMS1030586
pii:
doi:
Substances chimiques
Carbon Isotopes
0
Pyruvate Dehydrogenase Complex
0
Water
059QF0KO0R
Lactic Acid
33X04XA5AT
Pyruvic Acid
8558G7RUTR
Deuterium
AR09D82C7G
L-Lactate Dehydrogenase
EC 1.1.1.27
Alanine Transaminase
EC 2.6.1.2
Alanine
OF5P57N2ZX
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
102-108Subventions
Organisme : NIBIB NIH HHS
ID : P41 EB015908
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL034557
Pays : United States
Organisme : NHLBI NIH HHS
ID : R37 HL034557
Pays : United States
Informations de copyright
Copyright © 2019. Published by Elsevier Inc.
Références
Anal Biochem. 2001 Feb 15;289(2):187-95
pubmed: 11161312
J Biol Chem. 1975 Oct 25;250(20):7961-7
pubmed: 1176455
J Biol Chem. 1976 Feb 25;251(4):1088-96
pubmed: 1249068
Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10158-63
pubmed: 12930897
NMR Biomed. 2004 Apr;17(2):51-9
pubmed: 15052552
J Biol Chem. 1977 Jul 25;252(14):5010-8
pubmed: 17612
Am J Physiol. 1990 Sep;259(3 Pt 2):H987-95
pubmed: 1975735
Trends Biochem Sci. 1991 Jan;16(1):5-10
pubmed: 2053137
Mol Biosyst. 2011 Oct;7(10):2834-6
pubmed: 21720636
J Biomol NMR. 2011 Dec;51(4):467-76
pubmed: 21984356
J Magn Reson. 2013 Mar;228:59-65
pubmed: 23357427
NMR Biomed. 2013 Dec;26(12):1831-43
pubmed: 24115045
Chem Soc Rev. 2014 Mar 7;43(5):1627-59
pubmed: 24363044
J Phys Chem B. 2014 Feb 6;118(5):1411-5
pubmed: 24397585
NMR Biomed. 2016 Apr;29(4):377-86
pubmed: 26777799
Circ Res. 2016 Nov 11;119(11):1177-1182
pubmed: 27635086
J Magn Reson. 2017 Nov;284:86-93
pubmed: 28972888
Chem Commun (Camb). 2018 May 17;54(41):5233-5236
pubmed: 29726563
J Biol Chem. 1988 May 25;263(15):6964-71
pubmed: 3284880
Eur J Biochem. 1973 Jul 16;36(2):369-79
pubmed: 4354336
Biochem J. 1983 Jan 15;210(1):193-8
pubmed: 6405740
Biochem J. 1982 Mar 15;202(3):573-9
pubmed: 7092831
Biochem J. 1982 Mar 15;202(3):589-602
pubmed: 7092833
Biochem J. 1981 Feb 1;193(2):401-6
pubmed: 7305939
Am J Physiol. 1996 Jan;270(1 Pt 2):H224-9
pubmed: 8769755