Acrotrione: An Oxidized Xanthene from the Roots of Acronychia pubescens.

Oxidation-Reduction Plant Roots / chemistry Rutaceae / chemistry Xanthenes / chemistry

Journal

Journal of natural products
ISSN: 1520-6025
Titre abrégé: J Nat Prod
Pays: United States
ID NLM: 7906882

Informations de publication

Date de publication:
26 04 2019
Historique:
pubmed: 14 3 2019
medline: 20 8 2020
entrez: 14 3 2019
Statut: ppublish

Résumé

A new oxidized xanthene, acrotrione (1), and two known acetophenones (2 and 3) were isolated from a methanol extract of the roots of Acronychia pubescens. The structure of 1 was elucidated on the basis of its (+)-HRESIMS, 2D NMR, and ECD data. Acritrione (1) contains an unusual oxidized furo[2,3- c]xanthene moiety that has not been previously reported. Moderate antiplasmodial activity for these natural products against chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum was determined with IC

Identifiants

DOI: 10.1021/acs.jnatprod.8b00956 PMID: 30865443
pubmed: 30865443
doi: 10.1021/acs.jnatprod.8b00956
doi:

Substances chimiques

Xanthenes 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1019-1023

Auteurs

Luke P Robertson (LP)

Environmental Futures Research Institute , Griffith University , Gold Coast Campus , Southport 4222 , Australia.
Griffith Institute for Drug Discovery , Griffith University , Nathan Campus , Brisbane 4111 , Australia.

Leonardo Lucantoni (L)

Griffith Institute for Drug Discovery , Griffith University , Nathan Campus , Brisbane 4111 , Australia.

Sandra Duffy (S)

Griffith Institute for Drug Discovery , Griffith University , Nathan Campus , Brisbane 4111 , Australia.

Vicky M Avery (VM)

Griffith Institute for Drug Discovery , Griffith University , Nathan Campus , Brisbane 4111 , Australia.

Anthony R Carroll (AR)

Environmental Futures Research Institute , Griffith University , Gold Coast Campus , Southport 4222 , Australia.
Griffith Institute for Drug Discovery , Griffith University , Nathan Campus , Brisbane 4111 , Australia.
ORCID: 0000-0001-7695-8301

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Classifications MeSH

questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Acrotrione: An Oxidized Xanthene from the...
questionsmedicales.fr › Structures de plante › Racines de plante › Acrotrione: An Oxidized Xanthene from the...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Rutaceae › Acrotrione: An Oxidized Xanthene from the...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Xanthènes › Acrotrione: An Oxidized Xanthene from the...