A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells.

AC133 Antigen / genetics Aldehyde Dehydrogenase 1 Family / antagonists & inhibitors Animals Antineoplastic Agents / pharmacology Cell Line, Tumor Drug Resistance, Neoplasm Enzyme Inhibitors / pharmacology Female Humans Mice Necroptosis Neoplastic Stem Cells / drug effects Ovarian Neoplasms / metabolism Oxidative Phosphorylation Retinal Dehydrogenase / antagonists & inhibitors
ALDH CD133(+) CSC cell death necroptosis ovarian cancer resistance

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
12 03 2019
Historique:
received: 15 09 2018
revised: 19 01 2019
accepted: 07 02 2019
entrez: 14 3 2019
pubmed: 14 3 2019
medline: 16 4 2020
Statut: ppublish

Résumé

Ovarian cancer is typified by the development of chemotherapy resistance. Chemotherapy resistance is associated with high aldehyde dehydrogenase (ALDH) enzymatic activity, increased cancer "stemness," and expression of the stem cell marker CD133. As such, ALDH activity has been proposed as a therapeutic target. Although it remains controversial which of the 19 ALDH family members drive chemotherapy resistance, ALDH1A family members have been primarily linked with chemotherapy resistant and stemness. We identified two ALDH1A family selective inhibitors (ALDH1Ai). ALDH1Ai preferentially kills CD133

Identifiants

DOI: 10.1016/j.celrep.2019.02.032 PMID: 30865894 PMC: PMC7061440
pubmed: 30865894
pii: S2211-1247(19)30203-7
doi: 10.1016/j.celrep.2019.02.032
pmc: PMC7061440
mid: NIHMS1564955
pii:
doi:

Substances chimiques

AC133 Antigen 0
Antineoplastic Agents 0
Enzyme Inhibitors 0
Aldehyde Dehydrogenase 1 Family EC 1.2.1
ALDH1A1 protein, mouse EC 1.2.1.36
Retinal Dehydrogenase EC 1.2.1.36

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

3061-3075.e6

Subventions

Organisme : NCI NIH HHS
ID : R01 CA203810
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES024872
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA214567
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA209978
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM101171
Pays : United States

Informations de copyright

Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.

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Auteurs

Ilana Chefetz (I)

Division of Hematology-Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

Edward Grimley (E)

Division of Hematology-Oncology, Department of Internal Medicine, Division of Gynecology-Oncology, Department of Obstetrics and Gynecology, and UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.

Kun Yang (K)

Division of Hematology-Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

Linda Hong (L)

Division of Gynecology-Oncology, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.

Ekaterina V Vinogradova (EV)

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.

Radu Suciu (R)

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.

Ilya Kovalenko (I)

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.

David Karnak (D)

Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.

Cynthia A Morgan (CA)

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.

Mikhail Chtcherbinine (M)

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.

Cameron Buchman (C)

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.

Brandt Huddle (B)

Vahlteich Medicinal Chemistry Core, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.

Scott Barraza (S)

Vahlteich Medicinal Chemistry Core, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.

Meredith Morgan (M)

Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.

Kara A Bernstein (KA)

Department of Microbiology and Molecular Genetics, University of Pittsburgh, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.

Euisik Yoon (E)

Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, USA.

David B Lombard (DB)

Department of Pathology and Institute of Gerontology, University of Michigan, Ann Arbor, MI, USA.

Andrea Bild (A)

Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA.

Geeta Mehta (G)

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.

Iris Romero (I)

Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, IL, USA.

Chun-Yi Chiang (CY)

Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, IL, USA.

Charles Landen (C)

Department of Obstetrics and Gynecology, School of Medicine, University of Virginia, Charlottesville, VA, USA.

Benjamin Cravatt (B)

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.

Thomas D Hurley (TD)

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.

Scott D Larsen (SD)

Vahlteich Medicinal Chemistry Core, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.

Ronald J Buckanovich (RJ)

Division of Hematology-Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Division of Gynecology-Oncology, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA; Division of Hematology-Oncology, Department of Internal Medicine, Division of Gynecology-Oncology, Department of Obstetrics and Gynecology, and UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA; Magee-Womens Research Institute, Pittsburgh, PA, USA. Electronic address: buckanovichrj@mwri.magee.edu.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › Antigène AC133 › A Pan-ALDH1A Inhibitor Induces Necroptosis in...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on aldehyde or oxo group donors › Aldehyde oxidoreductases › Aldehyde dehydrogenase › Aldehyde dehydrogenase 1 › A Pan-ALDH1A Inhibitor Induces Necroptosis in...
questionsmedicales.fr › Eucaryotes › Animaux › A Pan-ALDH1A Inhibitor Induces Necroptosis in...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › A Pan-ALDH1A Inhibitor Induces Necroptosis in...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › A Pan-ALDH1A Inhibitor Induces Necroptosis in...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance aux médicaments antinéoplasiques › A Pan-ALDH1A Inhibitor Induces Necroptosis in...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › A Pan-ALDH1A Inhibitor Induces Necroptosis in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A Pan-ALDH1A Inhibitor Induces Necroptosis in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A Pan-ALDH1A Inhibitor Induces Necroptosis in...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Nécroptose › A Pan-ALDH1A Inhibitor Induces Necroptosis in...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches tumorales › A Pan-ALDH1A Inhibitor Induces Necroptosis in...
questionsmedicales.fr › Maladies endocriniennes › Troubles gonadiques › Maladies ovariennes › Tumeurs de l'ovaire › A Pan-ALDH1A Inhibitor Induces Necroptosis in...
questionsmedicales.fr › Métabolisme › Phosphorylation › Phosphorylation oxydative › A Pan-ALDH1A Inhibitor Induces Necroptosis in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Métalloprotéines › Protéines de liaison au fer › Protéines à fer non hème › Retinal dehydrogenase › A Pan-ALDH1A Inhibitor Induces Necroptosis in...