Triterpene-Based Carboxamides Act as Good Inhibitors of Butyrylcholinesterase.
acetylcholinesterase
butyrylcholinesterase
triterpenoids
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
07 Mar 2019
07 Mar 2019
Historique:
received:
12
02
2019
revised:
25
02
2019
accepted:
02
03
2019
entrez:
15
3
2019
pubmed:
15
3
2019
medline:
27
6
2019
Statut:
epublish
Résumé
A set of overall 40 carboxamides was prepared from five different natural occurring triterpenoids including oleanolic, ursolic, maslinic, betulinic, and platanic acid. All of which were derived from ethylene diamine holding an additional substituent connected to the ethylene diamine group. These derivatives were evaluated regarding their inhibitory activity of the enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) employing Ellman's assay. We further determined the type of inhibition and inhibition constants. Carboxamides derived from platanic acid have been shown to be potent and selective BChE inhibitors. Especially the mixed-type inhibitor (3β)-
Identifiants
pubmed: 30866589
pii: molecules24050948
doi: 10.3390/molecules24050948
pmc: PMC6429507
pii:
doi:
Substances chimiques
Cholinesterase Inhibitors
0
Triterpenes
0
platanic acid
6060-06-6
Acetylcholinesterase
EC 3.1.1.7
Butyrylcholinesterase
EC 3.1.1.8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Med Res Rev. 2018 May;38(3):951-976
pubmed: 29350407
Bioorg Chem. 2016 Oct;68:137-51
pubmed: 27518757
Food Chem. 2011 Sep 15;128(2):495-9
pubmed: 25212161
Bioorg Chem. 2017 Oct;74:145-157
pubmed: 28797788
Biochem J. 1974 Jan;137(1):143-4
pubmed: 4206907
Bioorg Chem. 2019 Sep;90:103092
pubmed: 31280014
J Med Chem. 2016 Mar 24;59(6):2396-409
pubmed: 26908173
Molecules. 2018 Oct 08;23(10):
pubmed: 30297604
Eur J Med Chem. 2018 Jan 1;143:259-265
pubmed: 29197730
J Enzyme Inhib Med Chem. 2015 Feb;30(1):133-9
pubmed: 24666300
Biochem J. 1953 Aug;55(1):170-1
pubmed: 13093635
Lancet. 1976 Dec 25;2(8000):1403
pubmed: 63862
Z Naturforsch C J Biosci. 2007 Sep-Oct;62(9-10):668-72
pubmed: 18069238
Eur J Med Chem. 2015 Oct 20;103:438-45
pubmed: 26383128
Bioorg Chem. 2019 Apr;85:23-32
pubmed: 30599410
Bioorg Med Chem. 2014 Jan 1;22(1):594-615
pubmed: 24268794
Neuropathol Appl Neurobiol. 1978 Jul-Aug;4(4):273-7
pubmed: 703927
Eur J Med Chem. 2017 Jan 27;126:652-668
pubmed: 27936444
Curr Med Chem. 2018;25(10):1259-1269
pubmed: 28820068