Kappa opioid signaling in the right central amygdala causes hind paw specific loss of diffuse noxious inhibitory controls in experimental neuropathic pain.
Amygdala
/ physiopathology
Animals
Chronic Pain
/ physiopathology
Diffuse Noxious Inhibitory Control
/ drug effects
Electrophysiological Phenomena
Functional Laterality
Hindlimb
/ innervation
Hyperalgesia
/ drug therapy
Ligation
Male
Naltrexone
/ analogs & derivatives
Neuralgia
/ physiopathology
Pain Measurement
Rats
Rats, Sprague-Dawley
Receptors, Opioid, kappa
/ antagonists & inhibitors
Signal Transduction
Spinal Nerves
/ physiopathology
Journal
Pain
ISSN: 1872-6623
Titre abrégé: Pain
Pays: United States
ID NLM: 7508686
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
pubmed:
15
3
2019
medline:
21
5
2020
entrez:
15
3
2019
Statut:
ppublish
Résumé
Diffuse noxious inhibitory controls (DNICs) is a pain-inhibits-pain phenomenon demonstrated in humans and animals. Diffuse noxious inhibitory control is diminished in many chronic pain states, including neuropathic pain. The efficiency of DNIC has been suggested to prospectively predict both the likelihood of pain chronification and treatment response. Little is known as to why DNIC is dysfunctional in neuropathic pain. Here, we evaluated DNIC in the rat L5/L6 spinal nerve ligation (SNL) model of chronic pain using both behavioral and electrophysiological outcomes. For behavior, nociceptive thresholds were determined using response to noxious paw pressure on both hind paws as the test stimulus before, and after, injection of a conditioning stimulus of capsaicin into the left forepaw. Functionally, the spike firing of spinal wide-dynamic-range neuronal activity was evaluated before and during noxious ear pinch, while stimulating the ipsilateral paw with von Frey hairs of increased bending force. In both assays, the DNIC response was significantly diminished in the ipsilateral (ie, injured) paw of SNL animals. However, behavioral loss of DNIC was not observed on the contralateral (ie, uninjured) paw. Systemic application of nor-binaltorphimine, a kappa opioid antagonist, did not ameliorate SNL-induced hyperalgesia but reversed loss of the behavioral DNIC response. Microinjection of nor-binaltorphimine into the right central amygdala (RCeA) of SNL rats did not affect baseline thresholds but restored DNIC both behaviorally and electrophysiologically. Cumulatively, these data suggest that net enhanced descending facilitations may be mediated by kappa opioid receptor signaling from the right central amygdala to promote diminished DNIC after neuropathy.
Identifiants
pubmed: 30870321
doi: 10.1097/j.pain.0000000000001553
pii: 00006396-201907000-00015
doi:
Substances chimiques
Receptors, Opioid, kappa
0
norbinaltorphimine
36OOQ86QM1
Naltrexone
5S6W795CQM
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1614-1621Subventions
Organisme : Wellcome Trust
ID : 102645
Pays : United Kingdom
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