Oxytocin alters patterns of brain activity and amygdalar connectivity by age during dynamic facial emotion identification.
Aging
Amygdala
Emotion
Functional connectivity
Oxytocin
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
03
10
2018
revised:
03
01
2019
accepted:
21
01
2019
pubmed:
15
3
2019
medline:
10
7
2019
entrez:
15
3
2019
Statut:
ppublish
Résumé
Aging is associated with increased difficulty in facial emotion identification, possibly due to age-related network change. The neuropeptide oxytocin (OT) facilitates emotion identification, but this is understudied in aging. To determine the effects of OT on dynamic facial emotion identification across adulthood, 46 young and 48 older participants self-administered intranasal OT or a placebo in a randomized, double-blind procedure. Older participants were slower and less accurate in identifying emotions. Although there was no behavioral treatment effect, partial least squares analysis supported treatment effects on brain patterns during emotion identification that varied by age and emotion. For young participants, OT altered the processing of sadness and happiness, whereas for older participants, OT only affected the processing of sadness (15.3% covariance, p = 0.004). Furthermore, seed partial least squares analysis showed that older participants in the OT group recruited a large-scale amygdalar network that was positively correlated for anger, fear, and happiness, whereas older participants in the placebo group recruited a smaller, negatively correlated network (7% covariance, p = 0.002). Advancing the literature, these findings show that OT alters brain activity and amygdalar connectivity by age and emotion.
Identifiants
pubmed: 30870779
pii: S0197-4580(19)30030-2
doi: 10.1016/j.neurobiolaging.2019.01.016
pmc: PMC6545147
mid: NIHMS1519862
pii:
doi:
Substances chimiques
Oxytocin
50-56-6
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
42-51Subventions
Organisme : NIAAA NIH HHS
ID : K01 AA025306
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000064
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG028740
Pays : United States
Organisme : NIA NIH HHS
ID : R24 AG054355
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR001429
Pays : United States
Organisme : NIA NIH HHS
ID : R24 AG039350
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG020499
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
Références
Annu Rev Psychol. 2010;61:383-409
pubmed: 19575618
Nat Rev Neurosci. 2015 Jan;16(1):55-61
pubmed: 25406711
Psychoneuroendocrinology. 2009 Feb;34(2):220-5
pubmed: 18848401
Perspect Psychol Sci. 2011 Mar;6(2):114-33
pubmed: 21660127
Neuroimage. 2002 Jan;15(1):273-89
pubmed: 11771995
PLoS One. 2013;8(2):e58113
pubmed: 23469148
Brain Connect. 2012;2(3):125-41
pubmed: 22642651
Neuroimage. 2005 Nov 15;28(3):635-62
pubmed: 16172003
Front Psychol. 2015 May 21;6:663
pubmed: 26052298
Gerontology. 2013;59(1):32-9
pubmed: 22922544
Nat Methods. 2011 Jun 26;8(8):665-70
pubmed: 21706013
Cogn Emot. 2016 Aug;30(5):939-52
pubmed: 25964985
Psychoneuroendocrinology. 2013 Jul;38(7):962-74
pubmed: 23159011
Neurobiol Aging. 2014 Oct;35(10):2246-8
pubmed: 24856057
Am J Primatol. 2018 Oct;80(10):e22735
pubmed: 29350419
J Psychopharmacol. 2009 May;23(3):241-8
pubmed: 18801829
Psychol Aging. 2009 Dec;24(4):863-78
pubmed: 20025402
Psychoneuroendocrinology. 2010 Jan;35(1):83-93
pubmed: 19632787
Neuropsychopharmacology. 2013 Sep;38(10):1929-36
pubmed: 23575742
Neuropsychologia. 2017 Jan 8;94:1-12
pubmed: 27865969
Int J Psychophysiol. 2019 Feb;136:22-32
pubmed: 29410310
Psychoneuroendocrinology. 2013 Jul;38(7):1198-202
pubmed: 23117026
J Pers Soc Psychol. 1988 Jun;54(6):1063-70
pubmed: 3397865
Psychol Aging. 2017 Feb;32(1):93-103
pubmed: 27977219
Transl Psychiatry. 2015 Oct 27;5:e664
pubmed: 26506050
Neuroimage. 2007 Aug 1;37(1):90-101
pubmed: 17560126
Psychol Aging. 2004 Mar;19(1):211-4
pubmed: 15065945
Neuroimage. 1996 Jun;3(3 Pt 1):143-57
pubmed: 9345485
Biol Psychiatry. 2007 Nov 15;62(10):1187-90
pubmed: 17617382
J Cogn Neurosci. 2015 Dec;27(12):2462-76
pubmed: 26351864
Rev Neurosci. 2003;14(4):303-16
pubmed: 14640318
J Neurosci. 2005 Dec 7;25(49):11489-93
pubmed: 16339042
Brain Connect. 2017 Sep;7(7):454-463
pubmed: 28762756
Soc Cogn Affect Neurosci. 2007 Dec;2(4):292-302
pubmed: 18985135
Front Neurosci. 2013 Jan 10;6:194
pubmed: 23335876
Front Psychol. 2014 Sep 09;5:996
pubmed: 25250002
Trends Cogn Sci. 2011 Feb;15(2):85-93
pubmed: 21167765
Cogn Emot. 2009 Feb 1;23(2):209-237
pubmed: 19809584
Emotion. 2012 Oct;12(5):1161-79
pubmed: 22081890
J Cogn Neurosci. 2012 Nov;24(11):2186-98
pubmed: 22784277
Biol Psychiatry. 2016 Feb 1;79(3):194-202
pubmed: 26321019
J Cogn Neurosci. 2013 Aug;25(8):1206-24
pubmed: 23530897
Ther Deliv. 2018 Jul;9(7):515-525
pubmed: 29943688
Psychoneuroendocrinology. 2012 Apr;37(4):475-81
pubmed: 21862223
Front Hum Neurosci. 2013 Aug 28;7:487
pubmed: 24009568
Proc Natl Acad Sci U S A. 2010 May 18;107(20):9400-5
pubmed: 20421469
Psychoneuroendocrinology. 2016 Jul;69:50-9
pubmed: 27032063
Front Psychol. 2015 Aug 04;6:1130
pubmed: 26300822
Neurobiol Aging. 2010 Feb;31(2):315-27
pubmed: 18455837
Psychoneuroendocrinology. 2013 Sep;38(9):1797-802
pubmed: 23562249
Cogn Affect Behav Neurosci. 2009 Sep;9(3):237-41
pubmed: 19679759
Neuroimage. 2011 May 15;56(2):455-75
pubmed: 20656037
Emotion. 2009 Jun;9(3):329-39
pubmed: 19485610
Front Neurosci. 2013 Mar 15;7:35
pubmed: 23508240
Neuroimage. 2004;23 Suppl 1:S250-63
pubmed: 15501095
Neurobiol Aging. 2016 Dec;48:182-194
pubmed: 27716474
Neurosci Biobehav Rev. 2008;32(4):811-30
pubmed: 18316124
Behav Cogn Neurosci Rev. 2002 Mar;1(1):21-62
pubmed: 17715585
Expert Opin Drug Discov. 2011 Jun 1;6(6):597-617
pubmed: 21765857
Neuropsychologia. 2014 Oct;63:235-48
pubmed: 25152530
Neuropsychologia. 2003;41(2):195-202
pubmed: 12459217
Horm Behav. 2018 Mar;99:25-34
pubmed: 29408521
Behav Res Methods. 2010 Feb;42(1):351-62
pubmed: 20160315
Behav Neurol. 2000;12(4):191-200
pubmed: 11568431
Psychoneuroendocrinology. 2013 May;38(5):612-25
pubmed: 23265311
Neurosci Biobehav Rev. 2008;32(4):863-81
pubmed: 18276008
Front Aging Neurosci. 2015 Sep 10;7:175
pubmed: 26441637
Emotion. 2013 Apr;13(2):238-49
pubmed: 23163713
Brain. 2011 Sep;134(Pt 9):2493-501
pubmed: 21859765
PLoS One. 2015 Sep 24;10(9):e0137514
pubmed: 26402337
Neurosci Biobehav Rev. 2017 Jul;78:125-144
pubmed: 28467893
Psychosoc Med. 2011 Apr 20;8:Doc03
pubmed: 21522486
Cereb Cortex. 2003 Oct;13(10):1023-33
pubmed: 12967919