Female risk-adjusted survival advantage after injuries caused by falls, traffic or assault: a nationwide 11-year study.
Accidental Falls
/ mortality
Accidents, Traffic
/ mortality
Adolescent
Adult
Aged
Aged, 80 and over
Cause of Death
/ trends
Child
Child, Preschool
Female
Follow-Up Studies
Forecasting
Hospitalization
/ trends
Humans
Infant
Infant, Newborn
Injury Severity Score
Male
Middle Aged
Population Surveillance
Registries
Retrospective Studies
Sex Distribution
Sex Factors
Survival Rate
/ trends
Sweden
/ epidemiology
Wounds and Injuries
/ etiology
Young Adult
Epidemiological
ICISS
Injury
Nationwide
Risk-adjusted mortality
Trauma
Journal
Scandinavian journal of trauma, resuscitation and emergency medicine
ISSN: 1757-7241
Titre abrégé: Scand J Trauma Resusc Emerg Med
Pays: England
ID NLM: 101477511
Informations de publication
Date de publication:
15 Mar 2019
15 Mar 2019
Historique:
received:
21
09
2018
accepted:
06
02
2019
entrez:
16
3
2019
pubmed:
16
3
2019
medline:
8
5
2019
Statut:
epublish
Résumé
A female survival advantage after injury has been observed, and animal models of trauma have suggested either hormonal or genetic mechanisms as component causes. Our aim was to compare age and risk-adjusted sex-related mortality in hospital for the three most common mechanisms of injury in relation to hormonal effects as seen by age. All hospital admissions for injury in Sweden during the period 2001-2011 were retrieved from the National Patient Registry and linked to the Cause of Death Registry. The International Classification of Diseases Injury Severity Score (ICISS) was used to adjust for injury severity, and the Charlson Comorbidity Index to adjust for comorbidity. Age categories (0-14, 15-50, and ≥ 51 years) were used to represent pre-menarche, reproductive and post- menopausal women. Women had overall a survival benefit (OR 0.51; 95% CI 0.50 to 0.53) after adjustment for injury severity and comorbidity. A similar pattern was seen across the age categories (0-14 years OR 0.56 (95% CI 0.25 to 1.25), 15-50 years OR 0.70 (95% CI 0.57 to 0.87), and ≥ 51 years OR 0.49 (95% CI 0.48 to 0.51)). In this 11-year population-based study we found no support for an oestrogen-related mechanism to explain the survival advantage for females compared to males following hospitalisation for injury.
Sections du résumé
BACKGROUND
BACKGROUND
A female survival advantage after injury has been observed, and animal models of trauma have suggested either hormonal or genetic mechanisms as component causes. Our aim was to compare age and risk-adjusted sex-related mortality in hospital for the three most common mechanisms of injury in relation to hormonal effects as seen by age.
METHODS
METHODS
All hospital admissions for injury in Sweden during the period 2001-2011 were retrieved from the National Patient Registry and linked to the Cause of Death Registry. The International Classification of Diseases Injury Severity Score (ICISS) was used to adjust for injury severity, and the Charlson Comorbidity Index to adjust for comorbidity. Age categories (0-14, 15-50, and ≥ 51 years) were used to represent pre-menarche, reproductive and post- menopausal women.
RESULTS
RESULTS
Women had overall a survival benefit (OR 0.51; 95% CI 0.50 to 0.53) after adjustment for injury severity and comorbidity. A similar pattern was seen across the age categories (0-14 years OR 0.56 (95% CI 0.25 to 1.25), 15-50 years OR 0.70 (95% CI 0.57 to 0.87), and ≥ 51 years OR 0.49 (95% CI 0.48 to 0.51)).
CONCLUSION
CONCLUSIONS
In this 11-year population-based study we found no support for an oestrogen-related mechanism to explain the survival advantage for females compared to males following hospitalisation for injury.
Identifiants
pubmed: 30871611
doi: 10.1186/s13049-019-0597-3
pii: 10.1186/s13049-019-0597-3
pmc: PMC6419337
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
24Références
Arch Surg. 1999 Dec;134(12):1342-7
pubmed: 10593332
Am J Physiol Cell Physiol. 2001 Oct;281(4):C1131-8
pubmed: 11546648
Ann Surg. 2002 Jan;235(1):105-12
pubmed: 11753049
Shock. 2003 Jan;19(1):28-32
pubmed: 12558140
J Trauma. 2003 Mar;54(3):464-71
pubmed: 12634524
Inj Prev. 2004 Dec;10(6):379-83
pubmed: 15583261
J Burn Care Rehabil. 2005 Sep-Oct;26(5):416-21
pubmed: 16151287
N Engl J Med. 2006 Jan 26;354(4):366-78
pubmed: 16436768
Clinics (Sao Paulo). 2006 Oct;61(5):479-88
pubmed: 17072448
Shock. 2007 Jun;27(6):597-604
pubmed: 17505297
Injury. 2007 Dec;38(12):1382-91
pubmed: 18048037
Mol Med. 2008 Mar-Apr;14(3-4):213-21
pubmed: 18235843
J Am Coll Surg. 2008 May;206(5):984-91; discussion 991-2
pubmed: 18471739
Health Rep. 2008 Sep;19(3):45-51
pubmed: 18847144
Climacteric. 2009 Oct;12(5):410-8
pubmed: 19415542
Inj Prev. 2011 Apr;17(2):108-13
pubmed: 21113015
Clin Epidemiol. 2011;3:203-11
pubmed: 21750629
J Trauma. 2011 Dec;71(6):1652-8
pubmed: 22182874
J Trauma Acute Care Surg. 2012 Mar;72(3):765-72
pubmed: 22491568
Surgery. 2012 Aug;152(2):179-85
pubmed: 22727364
J Neurotrauma. 2012 Oct 8;:null
pubmed: 23039042
J Trauma Acute Care Surg. 2014 Feb;76(2):358-65
pubmed: 24398769
Injury. 2014 Oct;45 Suppl 3:S20-8
pubmed: 25284229
Crit Care. 2015 Mar 30;19:129
pubmed: 25887421
BMC Res Notes. 2016 Oct 28;9(1):482
pubmed: 27793196
Scand J Trauma Resusc Emerg Med. 2017 May 2;25(1):47
pubmed: 28464944
Scand J Trauma Resusc Emerg Med. 2018 Apr 3;26(1):24
pubmed: 29615089
J Chronic Dis. 1987;40(5):373-83
pubmed: 3558716
J Trauma. 1996 Sep;41(3):380-6; discussion 386-8
pubmed: 8810953
Ann Surg. 1998 Jun;227(6):790-9
pubmed: 9637542
Am J Physiol. 1998 Jun;274(6):C1530-6
pubmed: 9696695