Hippocampal Contributions to Model-Based Planning and Spatial Memory.
anterior temporal lobe
decision-making
hippocampus
human
lesion
memory
model-based
planning
reinforcement learning
spatial
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
08 05 2019
08 05 2019
Historique:
received:
29
05
2018
revised:
21
12
2018
accepted:
08
02
2019
pubmed:
16
3
2019
medline:
13
11
2019
entrez:
16
3
2019
Statut:
ppublish
Résumé
Little is known about the neural mechanisms that allow humans and animals to plan actions using knowledge of task contingencies. Emerging theories hypothesize that it involves the same hippocampal mechanisms that support self-localization and memory for locations. Yet limited direct evidence supports the link between planning and the hippocampal place map. We addressed this by investigating model-based planning and place memory in healthy controls and epilepsy patients treated using unilateral anterior temporal lobectomy with hippocampal resection. Both functions were impaired in the patient group. Specifically, the planning impairment was related to right hippocampal lesion size, controlling for overall lesion size. Furthermore, although planning and boundary-driven place memory covaried in the control group, this relationship was attenuated in patients, consistent with both functions relying on the same structure in the healthy brain. These findings clarify both the neural mechanism of model-based planning and the scope of hippocampal contributions to behavior.
Identifiants
pubmed: 30871859
pii: S0896-6273(19)30123-0
doi: 10.1016/j.neuron.2019.02.014
pmc: PMC6508991
mid: NIHMS1523627
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
683-693.e4Subventions
Organisme : Wellcome Trust
ID : 202805/Z/16/Z
Pays : United Kingdom
Organisme : NIDA NIH HHS
ID : R01 DA038891
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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