Anti-Amphiphysin-associated limbic encephalitis in a 72-year-old patient with aortic angiosarcoma.
Aged
Aortic Diseases
/ complications
Bone Neoplasms
/ complications
Drug Therapy
/ methods
Fatal Outcome
Hemangiosarcoma
Humans
Immunosuppressive Agents
/ therapeutic use
Kidney Neoplasms
/ complications
Limbic Encephalitis
/ complications
Male
Muscle Neoplasms
/ complications
Neoplasm Metastasis
/ pathology
Nephrectomy
/ methods
Nerve Tissue Proteins
/ antagonists & inhibitors
neurology
oncology
Journal
BMJ case reports
ISSN: 1757-790X
Titre abrégé: BMJ Case Rep
Pays: England
ID NLM: 101526291
Informations de publication
Date de publication:
14 Mar 2019
14 Mar 2019
Historique:
entrez:
16
3
2019
pubmed:
16
3
2019
medline:
27
6
2019
Statut:
epublish
Résumé
Paraneoplastic autoimmune encephalopathic syndromes have been described most often in association with small cell lung cancer or breast cancer, tumours of the ovaries, testes, lymphoma and thymoma. Antibodies associated with paraneoplastic encephalopathies are, among others, anti-Hu, anti-Ma2 and, in part, anti-N-methyl-D-aspartate(NMDA)-receptor antibodies. Here, we present the case of a 72-year-old patient hospitalised due to progressive cognitive decline and disorientation. Diagnostic workup revealed paraneoplastic anti-amphiphysin associated limbic encephalitis on the basis of an aortic angiosarcoma with metastases to kidney, muscle and bones. Highly aggressive chemotherapy as well as immunosuppressive therapy and cytoreductive laparoscopic nephrectomy were initiated. However, follow-up revealed further tumour progress and a worsening of neurological symptoms.
Identifiants
pubmed: 30872337
pii: 12/3/e226798
doi: 10.1136/bcr-2018-226798
pmc: PMC6424176
pii:
doi:
Substances chimiques
Immunosuppressive Agents
0
Nerve Tissue Proteins
0
amphiphysin
147954-52-7
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Curr Opin Neurol. 2014 Jun;27(3):361-8
pubmed: 24792345
AJNR Am J Neuroradiol. 2017 Jun;38(6):1070-1078
pubmed: 28183838
J Neuroophthalmol. 2006 Jun;26(2):107-12
pubmed: 16845310
J Thorac Cardiovasc Surg. 2010 Mar;139(3):e40-2
pubmed: 19660320
Clin Exp Dermatol. 2014 Jun;39(4):553-4
pubmed: 24707931
Neurology. 2013 Oct 22;81(17):1500-6
pubmed: 24068784
J Urol. 1991 Oct;146(4):1101-3
pubmed: 1895431
J Neurol. 2010 Apr;257(4):509-17
pubmed: 20035430
Arch Neurol. 1999 Feb;56(2):172-7
pubmed: 10025422
AJNR Am J Neuroradiol. 2015 Dec;36(12):2196-205
pubmed: 26381566
F1000 Biol Rep. 2009 Aug 17;1:61
pubmed: 20948622
Case Rep Med. 2011;2011:956089
pubmed: 21629818