Plant glutathione biosynthesis revisited: redox-mediated activation of glutamylcysteine ligase does not require homo-dimerization.
Amino Acid Sequence
Amino Acid Substitution
Arabidopsis
/ genetics
Arabidopsis Proteins
/ genetics
Catalytic Domain
Enzyme Activation
Glutamate-Cysteine Ligase
/ chemistry
Glutathione
/ biosynthesis
Kinetics
Models, Molecular
Mutagenesis, Site-Directed
Oxidation-Reduction
Plants, Genetically Modified
Protein Multimerization
Recombinant Proteins
/ chemistry
glutamylcysteine ligase
glutathione biosynthesis
homo-dimerization
redox activation
site-directed mutagenesis
Journal
The Biochemical journal
ISSN: 1470-8728
Titre abrégé: Biochem J
Pays: England
ID NLM: 2984726R
Informations de publication
Date de publication:
15 04 2019
15 04 2019
Historique:
received:
08
02
2019
revised:
08
02
2019
accepted:
04
03
2019
pubmed:
17
3
2019
medline:
11
2
2020
entrez:
17
3
2019
Statut:
epublish
Résumé
Plant γ-glutamylcysteine ligase (GCL), catalyzing the first and tightly regulated step of glutathione (GSH) biosynthesis, is redox-activated via formation of an intramolecular disulfide bond.
Identifiants
pubmed: 30877193
pii: BCJ20190072
doi: 10.1042/BCJ20190072
pmc: PMC6463388
doi:
Substances chimiques
Arabidopsis Proteins
0
Recombinant Proteins
0
Glutamate-Cysteine Ligase
EC 6.3.2.2
Glutathione
GAN16C9B8O
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1191-1203Informations de copyright
© 2019 The Author(s).
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