The Transcriptional Landscape of Marek's Disease Virus in Primary Chicken B Cells Reveals Novel Splice Variants and Genes.
CVI988/Rispens
ICP0
Marek’s disease virus (MDV)
RB1B
RNA-seq
polycistronic viral transcripts
primary B cells
splicing
transcriptome
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
16 03 2019
16 03 2019
Historique:
received:
18
02
2019
revised:
12
03
2019
accepted:
13
03
2019
entrez:
20
3
2019
pubmed:
20
3
2019
medline:
18
12
2019
Statut:
epublish
Résumé
Marek's disease virus (MDV) is an oncogenic alphaherpesvirus that infects chickens and poses a serious threat to poultry health. In infected animals, MDV efficiently replicates in B cells in various lymphoid organs. Despite many years of research, the viral transcriptome in primary target cells of MDV remained unknown. In this study, we uncovered the transcriptional landscape of the very virulent RB1B strain and the attenuated CVI988/Rispens vaccine strain in primary chicken B cells using high-throughput RNA-sequencing. Our data confirmed the expression of known genes, but also identified a novel spliced MDV gene in the unique short region of the genome. Furthermore,
Identifiants
pubmed: 30884829
pii: v11030264
doi: 10.3390/v11030264
pmc: PMC6466439
pii:
doi:
Substances chimiques
Protein Isoforms
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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