Diabetic cats have decreased gut microbial diversity and a lack of butyrate producing bacteria.
Animals
Bacteria
/ classification
Butyrates
/ metabolism
Cat Diseases
/ blood
Cats
Cross-Sectional Studies
DNA Barcoding, Taxonomic
DNA, Bacterial
/ isolation & purification
Denmark
Diabetes Mellitus
/ diet therapy
Diet, High-Protein
/ veterinary
Dysbiosis
/ blood
Feces
/ microbiology
Female
Fructosamine
/ blood
Gastrointestinal Microbiome
/ physiology
Male
Obesity
/ diet therapy
Prospective Studies
RNA, Ribosomal, 16S
/ genetics
Switzerland
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
18 03 2019
18 03 2019
Historique:
received:
30
04
2018
accepted:
26
02
2019
entrez:
20
3
2019
pubmed:
20
3
2019
medline:
29
10
2020
Statut:
epublish
Résumé
Obesity and inactivity are major risk factors of feline diabetes mellitus (FDM) and human type II diabetes mellitus (T2DM). In recent years, changes in the gut microbiota have been suggested as a contributing factor to T2DM. Whether the gut microbiota (GM) composition plays a role in FDM remains unknown. The aim of the current study was firstly a cross-sectional comparison of the GM of diabetic cats, to that of lean, and of obese/overweight non-diabetic cats of a similar age. Specifically, fecal samples from 82 privately-owned cats from Denmark and Switzerland were sequenced using 16S rRNA gene amplicon metabarcoding. Secondly dietary intervention data was generated, by obtaining additional samples from a subset of cats after placing them on a high-protein diet for four weeks. The GM diversity of diabetic cats was lower than that of lean cats in the cross-sectional study, and lower compared to lean and to overweight/obese cats after diet intervention. Diabetic cats also exhibited fewer Anaerotruncus, Dialister, and unknown Ruminococcaceae than lean cats. Serum fructosamine levels correlated negatively with Prevotellaceae abundance and positively with Enterobacteriaceae abundance. In summary the intestinal microbiota of diabetic cats was characterized by decreased GM diversity and loss of butyrate producing bacterial genera.
Identifiants
pubmed: 30886210
doi: 10.1038/s41598-019-41195-0
pii: 10.1038/s41598-019-41195-0
pmc: PMC6423039
doi:
Substances chimiques
Butyrates
0
DNA, Bacterial
0
RNA, Ribosomal, 16S
0
Fructosamine
4429-04-3
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
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