New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents.
Tuberculosis
antimycobacterial agent
drug design
molecular modelling
mycobactins
siderophores
Journal
Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
entrez:
21
3
2019
pubmed:
21
3
2019
medline:
6
4
2019
Statut:
ppublish
Résumé
Starting from the analysis of the hypothetical binding mode of our previous furan-based hit (I), we successfully achieved our objective to replace the nitro moiety, leading to the disclosure of a new lead exhibiting a strong activity against MbtI. Our best candidate 1 h displayed a K
Identifiants
pubmed: 30889995
doi: 10.1080/14756366.2019.1589462
pmc: PMC6427685
doi:
Substances chimiques
Antitubercular Agents
0
Enzyme Inhibitors
0
Furans
0
Lyases
EC 4.-
salicylate synthetase
EC 4.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
823-828Références
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