Effects of aged stored autologous red blood cells on human plasma metabolome.
Adult
Blood Preservation
/ adverse effects
Erythrocyte Transfusion
Erythrocytes
/ cytology
Healthy Volunteers
Humans
Immunologic Factors
/ blood
Inflammation Mediators
/ blood
Metabolome
Oxidants
/ blood
Plasma
/ metabolism
Plasticizers
/ analysis
Time Factors
Transplantation, Autologous
Vasoconstrictor Agents
/ blood
Journal
Blood advances
ISSN: 2473-9537
Titre abrégé: Blood Adv
Pays: United States
ID NLM: 101698425
Informations de publication
Date de publication:
26 03 2019
26 03 2019
Historique:
received:
07
12
2018
accepted:
15
02
2019
entrez:
21
3
2019
pubmed:
21
3
2019
medline:
28
3
2020
Statut:
ppublish
Résumé
Cold storage of blood for 5 to 6 weeks has been shown to impair endothelial function after transfusion and has been associated with measures of end-organ dysfunction. Although the products of hemolysis, such as cell-free plasma hemoglobin, arginase, heme, and iron, in part mediate these effects, a complete analysis of transfused metabolites that may affect organ function has not been evaluated to date. Blood stored for either 5 or 42 days was collected from 18 healthy autologous volunteers, prior to and after autologous transfusion into the forearm circulation, followed by metabolomics analyses. Significant metabolic changes were observed in the plasma levels of hemolytic markers, oxidized purines, plasticizers, and oxidized lipids in recipients of blood stored for 42 days, compared with 5 days. Notably, transfusion of day 42 red blood cells (RBCs) increased circulating levels of plasticizers (diethylhexyl phthalate and derivatives) by up to 18-fold. Similarly, transfusion of day 42 blood significantly increased circulating levels of proinflammatory oxylipins, including prostaglandins, hydroxyeicosatrienoic acids (HETEs), and dihydroxyoctadecenoic acids. Oxylipins were the most significantly increasing metabolites (for 9-HETE: up to ∼41-fold,
Identifiants
pubmed: 30890545
pii: bloodadvances.2018029629
doi: 10.1182/bloodadvances.2018029629
pmc: PMC6436007
doi:
Substances chimiques
Immunologic Factors
0
Inflammation Mediators
0
Oxidants
0
Plasticizers
0
Vasoconstrictor Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
884-896Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL098032
Pays : United States
Organisme : NIH HHS
ID : S10 OD021641
Pays : United States
Informations de copyright
© 2019 by The American Society of Hematology.
Références
Haematologica. 2016 May;101(5):578-86
pubmed: 26921359
J Biol Chem. 1980 Dec 25;255(24):11640-3
pubmed: 7440560
Gen Comp Endocrinol. 2015 Aug 1;219:74-88
pubmed: 25448254
Blood Transfus. 2010 Oct;8(4):220-36
pubmed: 20967163
N Engl J Med. 2015 Apr 9;372(15):1410-8
pubmed: 25853745
J Clin Invest. 2017 Jan 3;127(1):375-382
pubmed: 27941245
JAMA. 2015 Dec 15;314(23):2514-23
pubmed: 26637812
Proc Natl Acad Sci U S A. 1982 Apr;79(8):2460-4
pubmed: 6123997
Transfusion. 2011 Jul;51(7):1450-9
pubmed: 21251007
Transfusion. 2019 Jan;59(1):89-100
pubmed: 30353560
Haematologica. 2012 Jan;97(1):107-15
pubmed: 21993682
Blood. 2016 Sep 29;128(13):e43-50
pubmed: 27554084
Transfusion. 2016 Oct;56(10):2571-2583
pubmed: 27507802
Blood Adv. 2017 Jun 27;1(15):1132-1141
pubmed: 29034365
Anal Chem. 2010 Dec 1;82(23):9818-26
pubmed: 21049934
Transfusion. 2016 Feb;56(2):392-403
pubmed: 26477888
Transfusion. 2002 Jun;42(6):747-52
pubmed: 12147028
Blood Transfus. 2019 Jan;17(1):27-52
pubmed: 30653459
FASEB J. 2004 Nov;18(14):1746-8
pubmed: 15364894
Transfusion. 2015 Jan;55(1):205-19
pubmed: 25130459
Transfusion. 2015 Jun;55(6):1155-68
pubmed: 25556331
Biochemistry. 1987 Jan 13;26(1):52-9
pubmed: 3828308
Transfusion. 2017 Feb;57(2):325-336
pubmed: 27813142
Blood Transfus. 2014 Apr;12(2):204-9
pubmed: 24120596
Blood. 2016 Sep 22;128(12):e32-42
pubmed: 27405778
Transfusion. 2016 Apr;56(4):980-93
pubmed: 26662506
Front Med (Lausanne). 2017 Oct 17;4:175
pubmed: 29090212
Eur J Biochem. 2002 Apr;269(8):2032-9
pubmed: 11985579
Adv Nutr. 2015 Sep 15;6(5):513-40
pubmed: 26374175
EBioMedicine. 2016 Sep;11:239-248
pubmed: 27523807
J Mass Spectrom. 2015 Feb;50(2):326-35
pubmed: 25800014
Transfusion. 2016 Oct;56(10):2560-2570
pubmed: 27514704
Blood Transfus. 2016 Mar;14(2):140-4
pubmed: 26674826
JAMA. 2012 Oct 10;308(14):1443-51
pubmed: 23045213
Blood. 2010 May 27;115(21):4284-92
pubmed: 20299509
Immunity. 2013 Apr 18;38(4):633-43
pubmed: 23601682
Am J Respir Crit Care Med. 2015 Nov 15;192(10):1223-33
pubmed: 26222884
Eur J Biochem. 2000 Jul;267(14):4397-405
pubmed: 10880963
N Engl J Med. 2015 Apr 9;372(15):1419-29
pubmed: 25853746
Blood. 2013 Feb 28;121(9):1663-72
pubmed: 23255558
Transfus Med Rev. 2014 Apr;28(2):41-55
pubmed: 24636780
Transfusion. 2018 Aug;58(8):1992-2002
pubmed: 29624679
Trends Pharmacol Sci. 2011 Jan;32(1):16-24
pubmed: 21159389
Rapid Commun Mass Spectrom. 2017 Apr 30;31(8):663-673
pubmed: 28195377
Transfusion. 2016 Sep;56(9):2173-83
pubmed: 27301995
Mol Biosyst. 2013 Jun;9(6):1196-209
pubmed: 23426130
Nat Rev Drug Discov. 2015 Sep;14(9):623-41
pubmed: 26265312
Circulation. 2011 Jul 26;124(4):465-76
pubmed: 21747051
Vox Sang. 2017 May;112(4):326-335
pubmed: 28370161
FEBS J. 2007 Oct;274(20):5263-77
pubmed: 17892495
Vox Sang. 2015 Feb;108(2):131-40
pubmed: 25200932
Transfusion. 2011 Jul;51(7):1574-9
pubmed: 21251004
Transfusion. 2016 Jul;56(7):1690-8
pubmed: 27062463
Transfusion. 2018 Dec;58(12):2797-2806
pubmed: 30265764
Biochem J. 1988 Dec 15;256(3):689-95
pubmed: 3066352
Eur J Biochem. 1983 Sep 1;135(1):25-31
pubmed: 6224690
Transfusion. 2016 Oct;56(10):2538-2547
pubmed: 27491795
Blood Cells Mol Dis. 2009 May-Jun;42(3):192-200
pubmed: 19268612
Blood Transfus. 2014 Oct;12(4):548-56
pubmed: 24960643
Int J Tryptophan Res. 2009;2:71-9
pubmed: 22084583
Transfusion. 2016 Apr;56(4):852-62
pubmed: 26749434
J Proteomics. 2012 Dec 5;76 Spec No.:168-80
pubmed: 22465715
J Biol Chem. 1983 Jan 25;258(2):1189-96
pubmed: 6822497
Transfusion. 2018 Dec;58(12):2978-2991
pubmed: 30312994
Transfus Apher Sci. 2010 Aug;43(1):69-78
pubmed: 20646963
Transfusion. 2017 Apr;57(4):1019-1030
pubmed: 28295356
JAMA. 2005 Jul 6;294(1):81-90
pubmed: 15998894
Transfusion. 2015 Dec;55(12):2955-66
pubmed: 26271632
Am J Hematol. 2018 May;93(5):E110-E112
pubmed: 29352741
Blood Transfus. 2017 May;15(3):232-238
pubmed: 28518050
Am J Clin Exp Immunol. 2012 Sep 27;1(2):90-100
pubmed: 23885318
Haematologica. 2018 Feb;103(2):361-372
pubmed: 29079593
Blood Transfus. 2017 Mar;15(2):112-115
pubmed: 28263167
Transfusion. 2012 Jul;52(7):1388-92
pubmed: 22780890