Zika virus infection induces MiR34c expression in glioblastoma stem cells: new perspectives for brain tumor treatments.
Animals
Apoptosis
Brain Neoplasms
/ genetics
Cell Differentiation
/ genetics
Glioblastoma
/ genetics
High-Throughput Nucleotide Sequencing
Humans
Membrane Proteins
/ metabolism
Mice
MicroRNAs
/ genetics
Neoplastic Stem Cells
/ cytology
Nerve Tissue Proteins
/ metabolism
Neural Stem Cells
/ cytology
Transplantation, Heterologous
Zika Virus
/ growth & development
Journal
Cell death & disease
ISSN: 2041-4889
Titre abrégé: Cell Death Dis
Pays: England
ID NLM: 101524092
Informations de publication
Date de publication:
19 03 2019
19 03 2019
Historique:
received:
25
10
2018
accepted:
04
03
2019
revised:
28
02
2019
entrez:
21
3
2019
pubmed:
21
3
2019
medline:
16
5
2020
Statut:
epublish
Résumé
Zika virus (ZIKV) is a flavivirus with a marked effect on fetal nervous system development. ZIKV treatment has recently been found to also have a benefit against glioblastoma, a highly aggressive brain tumor with a poor prognosis. The reported data do not completely explain the mechanism beyond this effect. Nevertheless, in the majority of the cases no adverse effect has been found in healthy adult humans. In this study, we characterized the ZIKV infection mechanism on glioblastoma stem cells, which are considered responsible for the tumor progression and resistance to conventional therapies. Moreover, we explain why the action of this virus is directed to the stem cells in the nervous system counterpart. Our results confirm the effectiveness of ZIKV treatment against glioblastoma, indicating novel molecular targets that can be introduced for more powerful therapies.
Identifiants
pubmed: 30890698
doi: 10.1038/s41419-019-1499-z
pii: 10.1038/s41419-019-1499-z
pmc: PMC6425033
doi:
Substances chimiques
MIRN34 microRNA, human
0
Membrane Proteins
0
MicroRNAs
0
Nerve Tissue Proteins
0
NUMB protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
263Références
Bioinformatics. 2015 Jan 15;31(2):166-9
pubmed: 25260700
Mol Neurobiol. 2016 Sep;53(7):4509-20
pubmed: 26266644
Clin Cancer Res. 2008 Dec 15;14(24):8205-12
pubmed: 19088037
Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6844-9
pubmed: 10841580
Sci Rep. 2016 Feb 09;6:21557
pubmed: 26857460
J Exp Med. 2017 Oct 2;214(10):2843-2857
pubmed: 28874392
J Exp Med. 2004 Nov 15;200(10):1257-66
pubmed: 15545353
Crit Rev Oncol Hematol. 2008 Apr;66(1):42-51
pubmed: 18035551
Curr Biol. 2001 Apr 3;11(7):494-501
pubmed: 11412999
Nucleic Acids Res. 2015 Jul 1;43(W1):W460-6
pubmed: 25977294
Science. 2016 May 13;352(6287):816-8
pubmed: 27064148
Genome Biol. 2009;10(3):R25
pubmed: 19261174
Cell Transplant. 2016;25(2):353-64
pubmed: 25994834
Bioinformatics. 2014 Aug 1;30(15):2114-20
pubmed: 24695404
Genome Biol. 2014;15(12):550
pubmed: 25516281
Cancer Res. 2003 Sep 15;63(18):5821-8
pubmed: 14522905
J Neurooncol. 2012 Apr;107(2):359-64
pubmed: 22045118
Exp Ther Med. 2012 May;3(5):793-796
pubmed: 22969970
Cell Stem Cell. 2017 Mar 2;20(3):397-406.e5
pubmed: 28132835
Neuro Oncol. 2017 Jan;19(1):139-141
pubmed: 28031383
Sci Rep. 2015 Dec 01;5:17579
pubmed: 26620594
Cell Stem Cell. 2017 Jul 6;21(1):35-50.e9
pubmed: 28602620
Curr Infect Dis Rep. 2017 Jan;19(1):4
pubmed: 28220392
Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15178-83
pubmed: 14645703
Exp Neurol. 1999 Mar;156(1):71-83
pubmed: 10192778
Genome Announc. 2014 Jun 05;2(3):
pubmed: 24903869
Cell Death Dis. 2018 Mar 6;9(3):368
pubmed: 29511160
Cancer Res. 2004 Oct 1;64(19):7011-21
pubmed: 15466194
Science. 2005 Feb 18;307(5712):1098-101
pubmed: 15718470
BMC Cancer. 2002 May 31;2:15
pubmed: 12057025
Cell Stem Cell. 2016 Feb 4;18(2):189-202
pubmed: 26849305
Oncotarget. 2016 Mar 15;7(11):11785-802
pubmed: 26930720
Cell Death Dis. 2018 Feb 6;9(2):158
pubmed: 29410396