Vascular TSP1-CD47 signaling promotes sickle cell-associated arterial vasculopathy and pulmonary hypertension in mice.
Anemia, Sickle Cell
/ genetics
Animals
CD47 Antigen
/ antagonists & inhibitors
Cells, Cultured
Endothelial Cells
/ pathology
Humans
Hypertension, Pulmonary
/ genetics
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Pulmonary Artery
/ cytology
Reactive Oxygen Species
/ metabolism
Thrombospondin 1
/ metabolism
Ventricular Function, Right
/ physiology
oxidant stress
pulmonary hypertension
sickle cell disease
thrombospondin-1
transgenic mouse models
Journal
American journal of physiology. Lung cellular and molecular physiology
ISSN: 1522-1504
Titre abrégé: Am J Physiol Lung Cell Mol Physiol
Pays: United States
ID NLM: 100901229
Informations de publication
Date de publication:
01 06 2019
01 06 2019
Historique:
pubmed:
21
3
2019
medline:
25
3
2020
entrez:
21
3
2019
Statut:
ppublish
Résumé
Pulmonary hypertension (PH) is a leading cause of death in sickle cell disease (SCD) patients. Hemolysis and oxidative stress contribute to SCD-associated PH. We have reported that the protein thrombospondin-1 (TSP1) is elevated in the plasma of patients with SCD and, by interacting with its receptor CD47, limits vasodilation of distal pulmonary arteries ex vivo. We hypothesized that the TSP1-CD47 interaction may promote PH in SCD. We found that TSP1 and CD47 are upregulated in the lungs of Berkeley (BERK) sickling (Sickle) mice and patients with SCD-associated PH. We then generated chimeric animals by transplanting BERK bone marrow into C57BL/6J (
Identifiants
pubmed: 30892078
doi: 10.1152/ajplung.00302.2018
pmc: PMC6620668
doi:
Substances chimiques
CD47 Antigen
0
Cd47 protein, mouse
0
Reactive Oxygen Species
0
Thrombospondin 1
0
Thbs1 protein, mouse
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
L1150-L1164Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL079207
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142248
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL110849
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL103455
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL112914
Pays : United States
Références
J Biol Chem. 1999 Mar 26;274(13):8554-60
pubmed: 10085089
Blood. 1999 Jul 1;94(1):302-9
pubmed: 10381526
Hum Gene Ther. 1999 Dec 10;10(18):2927-40
pubmed: 10609654
Science. 2000 Jun 16;288(5473):2051-4
pubmed: 10856220
Ann N Y Acad Sci. 2000;899:375-91
pubmed: 10863554
Am J Physiol Regul Integr Comp Physiol. 2000 Dec;279(6):R1949-55
pubmed: 11080057
Am J Pathol. 2001 Mar;158(3):893-903
pubmed: 11238038
Blood. 2001 Apr 1;97(7):2159-64
pubmed: 11264185
Blood. 2001 Jun 15;97(12):3960-5
pubmed: 11389040
J Clin Invest. 2001 Jun;107(12):1555-62
pubmed: 11413163
Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15215-20
pubmed: 11752464
Curr Opin Hematol. 2002 Mar;9(2):101-6
pubmed: 11844991
Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3047-51
pubmed: 11880644
Immunol Res. 2002;26(1-3):107-18
pubmed: 12403350
Blood. 2003 May 15;101(10):3953-9
pubmed: 12543857
Angiogenesis. 1999;3(2):147-58
pubmed: 14517432
Blood. 2004 Mar 15;103(6):2397-400
pubmed: 14630831
N Engl J Med. 2004 Feb 26;350(9):886-95
pubmed: 14985486
Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13141-6
pubmed: 16150726
Cardiovasc Res. 2006 Sep 1;71(4):785-93
pubmed: 16820142
Blood. 2007 Mar 1;109(5):1945-52
pubmed: 17082319
Blood. 2007 Apr 1;109(7):3088-98
pubmed: 17158223
J Biol Chem. 2007 May 25;282(21):15404-15
pubmed: 17416590
Cell Mol Life Sci. 2008 Mar;65(5):728-42
pubmed: 18193160
Free Radic Biol Med. 2008 Apr 15;44(8):1506-28
pubmed: 18261470
Surgery. 2008 Nov;144(5):752-61
pubmed: 19081017
Am J Hematol. 2009 Jun;84(6):323-7
pubmed: 19358302
Plast Reconstr Surg. 2009 Dec;124(6):1880-9
pubmed: 19952644
J Biol Chem. 2010 May 7;285(19):14210-6
pubmed: 20194496
Blood. 2010 Jul 22;116(3):456-65
pubmed: 20304807
J Cardiothorac Surg. 2010 May 04;5:32
pubmed: 20441584
Cardiovasc Res. 2010 Dec 1;88(3):471-81
pubmed: 20610415
J Biol Chem. 2010 Dec 10;285(50):38923-32
pubmed: 20923780
Pharmacol Res. 2011 Jan;63(1):13-22
pubmed: 20971192
Arterioscler Thromb Vasc Biol. 2011 Mar;31(3):551-9
pubmed: 21148423
Blood Cells Mol Dis. 2011 Mar 15;46(3):220-5
pubmed: 21334230
Am J Hematol. 2011 Jun;86(6):484-9
pubmed: 21544855
N Engl J Med. 2011 Jul 7;365(1):44-53
pubmed: 21732836
Chest. 1990 Oct;98(4):1042
pubmed: 2209119
IUBMB Life. 2012 Jan;64(1):72-80
pubmed: 22131167
Cardiovasc Res. 2012 Mar 15;93(4):682-93
pubmed: 22215724
Am J Hematol. 2012 Mar;87(3):326-30
pubmed: 22318901
J Am Soc Nephrol. 2012 Sep;23(9):1538-50
pubmed: 22859854
Blood. 2012 Dec 13;120(25):5050-8
pubmed: 22976952
Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2966-73
pubmed: 23087362
Ann Surg. 2013 Jul;258(1):184-91
pubmed: 23275312
Am J Respir Crit Care Med. 2013 Apr 15;187(8):840-7
pubmed: 23348978
Blood. 2013 Mar 14;121(11):2099-107
pubmed: 23349388
Haematologica. 2013 Nov;98(11):e132-4
pubmed: 24186313
J Am Soc Nephrol. 2014 Jun;25(6):1171-86
pubmed: 24511121
Pulm Circ. 2013 Dec;3(4):936-51
pubmed: 25006410
Pulm Circ. 2013 Dec;3(4):952-8
pubmed: 25006411
Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15;308(4):L314-24
pubmed: 25398989
J Biol Chem. 2015 Nov 13;290(46):27939-58
pubmed: 26396189
Cardiovasc Res. 2016 Jan 1;109(1):115-30
pubmed: 26503986
Curr Pharm Des. 2015;21(41):6023-35
pubmed: 26510437
Ann N Y Acad Sci. 1989;565:316-26
pubmed: 2672967
Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1842-50
pubmed: 27199114
PLoS One. 2016 Jun 23;11(6):e0158287
pubmed: 27336623
Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):E5182-91
pubmed: 27503873
Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):E5308-17
pubmed: 27540115
Cardiovasc Res. 2017 Jan;113(1):15-29
pubmed: 27742621
J Alzheimers Dis. 2017;56(1):361-378
pubmed: 27911324
Sci Transl Med. 2017 Mar 15;9(381):
pubmed: 28298418
Cardiovasc Res. 2017 Jul 1;113(8):858-868
pubmed: 28472457
Sci Signal. 2017 Oct 17;10(501):
pubmed: 29042481
Proc Natl Acad Sci U S A. 1988 Jan;85(1):237-41
pubmed: 3422420
Trans Assoc Am Physicians. 1980;93:94-9
pubmed: 7245585
N Engl J Med. 1980 May 1;302(18):992-5
pubmed: 7366623
N Engl J Med. 1995 Jul 27;333(4):206-13
pubmed: 7791837
J Biol Chem. 1994 Jan 21;269(3):1567-70
pubmed: 8294396
Blood. 1993 Apr 15;81(8):2137-43
pubmed: 8471771
Am J Hematol. 1996 Apr;51(4):296-301
pubmed: 8602630
Science. 1996 Nov 1;274(5288):795-8
pubmed: 8864123
Hematol Oncol Clin North Am. 1996 Dec;10(6):1289-303
pubmed: 8956017
Blood. 1997 Apr 1;89(7):2560-7
pubmed: 9116303
Science. 1997 Oct 31;278(5339):876-8
pubmed: 9346488
N Engl J Med. 1997 Nov 27;337(22):1584-90
pubmed: 9371854
Exp Hematol. 1998 Apr;26(4):332-44
pubmed: 9546317
J Clin Invest. 1998 May 1;101(9):1899-904
pubmed: 9576754