MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM.
Animals
Antibodies, Bispecific
/ pharmacology
Antineoplastic Agents, Immunological
/ pharmacology
Cell Line, Tumor
Epithelial Cell Adhesion Molecule
/ antagonists & inhibitors
Hepatocyte Growth Factor
/ metabolism
Humans
Mice
Neoplasms, Experimental
/ drug therapy
Proto-Oncogene Proteins c-met
/ antagonists & inhibitors
Signal Transduction
/ drug effects
Xenograft Model Antitumor Assays
EpCAM
HGF
Met
bispecific antibody
cancer
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
09 04 2019
09 04 2019
Historique:
pubmed:
23
3
2019
medline:
23
5
2019
entrez:
23
3
2019
Statut:
ppublish
Résumé
Activation of the Met receptor tyrosine kinase, either by its ligand, hepatocyte growth factor (HGF), or via ligand-independent mechanisms, such as
Identifiants
pubmed: 30898885
pii: 1819085116
doi: 10.1073/pnas.1819085116
pmc: PMC6462049
doi:
Substances chimiques
Antibodies, Bispecific
0
Antineoplastic Agents, Immunological
0
EPCAM protein, human
0
Epithelial Cell Adhesion Molecule
0
HGF protein, human
0
Hepatocyte Growth Factor
67256-21-7
MET protein, human
EC 2.7.10.1
Proto-Oncogene Proteins c-met
EC 2.7.10.1
Banques de données
PDB
['6HYG', '6I07', '6I04']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7533-7542Déclaration de conflit d'intérêts
Conflict of interest statement: Several authors are or were employees of Merrimack Pharmaceuticals, Inc. at the time of contributing to the manuscript.
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