Astrocytic Epoxyeicosatrienoic Acid Signaling in the Medial Prefrontal Cortex Modulates Depressive-like Behaviors.
Adult
Animals
Arachidonic Acids
/ metabolism
Astrocytes
/ metabolism
Behavior, Animal
/ drug effects
Brain Chemistry
Cells, Cultured
Depressive Disorder, Major
/ genetics
Disease Models, Animal
Double-Blind Method
Eicosanoids
/ analysis
Epoxide Hydrolases
/ deficiency
Genes, Reporter
Genetic Vectors
/ administration & dosage
Humans
Lentivirus
/ genetics
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Middle Aged
Prefrontal Cortex
/ chemistry
Receptor, Fibroblast Growth Factor, Type 3
/ genetics
Signal Transduction
Stress, Psychological
/ metabolism
Suicide
Young Adult
ATP
astrocytes
depression
epoxyeicosatrienoic acid signaling
medial prefrontal cortex
soluble epoxide hydrolase
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
05 06 2019
05 06 2019
Historique:
received:
05
12
2018
revised:
17
03
2019
accepted:
18
03
2019
pubmed:
25
3
2019
medline:
23
6
2020
entrez:
24
3
2019
Statut:
ppublish
Résumé
Major depressive disorder is the most common mental illness. Mounting evidence indicates that astrocytes play a crucial role in the pathophysiology of depression; however, the underlying molecular mechanisms remain elusive. Compared with other neuronal cell types, astrocytes are enriched for arachidonic acid metabolism. Herein, we observed brain-region-specific alterations of epoxyeicosatrienoic acid (EET) signaling, which is an arachidonic acid metabolic pathway, in both a mouse model of depression and postmortem samples from patients with depression. The enzymatic activity of soluble epoxide hydrolase (sEH), the key enzyme in EET signaling, was selectively increased in the mPFC of susceptible mice after chronic social defeated stress and was negatively correlated with the social interaction ratio, which is an indicator of depressive-like behavior. The specific deletion of
Identifiants
pubmed: 30902874
pii: JNEUROSCI.3069-18.2019
doi: 10.1523/JNEUROSCI.3069-18.2019
pmc: PMC6554635
doi:
Substances chimiques
Arachidonic Acids
0
Eicosanoids
0
Fgfr3 protein, mouse
EC 2.7.10.1
Receptor, Fibroblast Growth Factor, Type 3
EC 2.7.10.1
Epoxide Hydrolases
EC 3.3.2.-
Ephx2 protein, mouse
EC 3.3.2.10
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4606-4623Informations de copyright
Copyright © 2019 the authors.
Références
Biol Psychiatry. 2000 Oct 15;48(8):861-73
pubmed: 11063981
J Neurosci. 2007 Apr 25;27(17):4642-9
pubmed: 17460077
Nat Cell Biol. 2007 Aug;9(8):945-53
pubmed: 17618272
Cell. 2007 Oct 19;131(2):391-404
pubmed: 17956738
J Neurosci. 2008 Jan 2;28(1):264-78
pubmed: 18171944
Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2838-44
pubmed: 18441205
Biol Psychiatry. 2008 Nov 15;64(10):863-70
pubmed: 18639237
Mol Psychiatry. 2010 May;15(5):501-11
pubmed: 18825147
Neuroscience. 2009 Oct 6;163(2):646-61
pubmed: 19540314
Neuropsychopharmacology. 2010 Jan;35(1):192-216
pubmed: 19693001
Glia. 2010 Jun;58(8):943-53
pubmed: 20155815
Neuroimage. 2011 Feb 14;54(4):2643-51
pubmed: 21073959
Nat Med. 2011 Apr;17(4):461-9
pubmed: 21399647
Curr Opin Cell Biol. 2011 Dec;23(6):730-7
pubmed: 21996102
Nat Rev Neurosci. 2011 Nov 30;13(1):22-37
pubmed: 22127301
Nat Med. 2012 Sep;18(9):1413-7
pubmed: 22885997
Annu Rev Pharmacol Toxicol. 2013;53:37-58
pubmed: 23020295
Science. 2013 Jan 11;339(6116):197-200
pubmed: 23307741
Transl Psychiatry. 2013 Jan 15;3:e212
pubmed: 23321809
J Biol Chem. 2013 Mar 15;288(11):7697-703
pubmed: 23362272
Nat Med. 2013 Jun;19(6):773-7
pubmed: 23644515
J Neurosci. 2014 Sep 3;34(36):11929-47
pubmed: 25186741
Nat Rev Neurosci. 2014 Dec;15(12):771-85
pubmed: 25387473
Cell. 2015 Jan 15;160(1-2):177-90
pubmed: 25594180
Drug Metab Dispos. 2015 May;43(5):788-802
pubmed: 25762541
Mol Psychiatry. 2016 Apr;21(4):509-15
pubmed: 26033239
Nat Neurosci. 2015 Nov;18(11):1539-1545
pubmed: 26505565
Science. 2016 Jan 1;351(6268):aac9698
pubmed: 26722001
Biol Psychiatry. 2016 Jul 1;80(1):12-22
pubmed: 26831917
Exp Neurobiol. 2016 Feb;25(1):48-54
pubmed: 26924933
Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1944-52
pubmed: 26976569
Neuron. 2017 Nov 1;96(3):697-708
pubmed: 29096081
J Chromatogr A. 2018 Aug 17;1563:144-153
pubmed: 29887336
Lancet. 1998 Apr 18;351(9110):1213
pubmed: 9643729
Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13290-5
pubmed: 9789081