Characterization of channel catfish (Ictalurus punctatus) melanocortin-3 receptor reveals a potential network in regulation of energy homeostasis.

Amino Acid Sequence Animals Base Sequence Chromosomes / genetics Cyclic AMP / metabolism Energy Metabolism Extracellular Signal-Regulated MAP Kinases / metabolism HEK293 Cells Homeostasis / drug effects Humans Ictaluridae / metabolism Ligands Phylogeny Receptor, Melanocortin, Type 3 / chemistry Sequence Analysis, DNA Signal Transduction Synteny / genetics
Channel catfish Constitutive activity Ligand binding Melanocortin receptor accessory protein 2 Melanocortin-3 receptor Signaling

Journal

General and comparative endocrinology
ISSN: 1095-6840
Titre abrégé: Gen Comp Endocrinol
Pays: United States
ID NLM: 0370735

Informations de publication

Date de publication:
01 06 2019
Historique:
received: 09 12 2018
revised: 12 03 2019
accepted: 18 03 2019
pubmed: 25 3 2019
medline: 20 9 2019
entrez: 26 3 2019
Statut: ppublish

Résumé

The melanocortin-3 receptor (MC3R) is known to be involved in regulation of energy homeostasis, regulating feed efficiency and nutrient partitioning in mammals. Its physiological roles in non-mammalian vertebrates, especially economically important aquaculture species, are not well understood. Channel catfish (Ictalurus punctatus) is the main freshwater aquaculture species in North America. In this study, we characterized the channel catfish MC3R. The mc3r of channel catfish encoded a putative protein (ipMC3R) of 367 amino acids. We transfected HEK293T cells with ipMC3R plasmid for functional studies. Five agonists, including adrenocorticotropin, α-melanocyte stimulating hormone (α-MSH), β-MSH, [Nle

Identifiants

DOI: 10.1016/j.ygcen.2019.03.011 PMID: 30905760
pubmed: 30905760
pii: S0016-6480(18)30670-1
doi: 10.1016/j.ygcen.2019.03.011
pii:
doi:

Substances chimiques

Ligands 0
Receptor, Melanocortin, Type 3 0
Cyclic AMP E0399OZS9N
Extracellular Signal-Regulated MAP Kinases EC 2.7.11.24

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

90-103

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Li-Kun Yang (LK)

Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, United States.

Zheng-Rui Zhang (ZR)

Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, United States; Key Laboratory of Marine Genetics and Breeding, Ministry of Education, College of Marine Life Sciences, Ocean University of China, Qingdao, China.

Hai-Shen Wen (HS)

College of Fisheries, Ocean University of China, Qingdao, China.

Ya-Xiong Tao (YX)

Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, United States. Electronic address: taoyaxi@auburn.edu.

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › Characterization of channel catfish (Ictalurus...
questionsmedicales.fr › Eucaryotes › Animaux › Characterization of channel catfish (Ictalurus...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence nucléotidique › Characterization of channel catfish (Ictalurus...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Chromosomes › Characterization of channel catfish (Ictalurus...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › AMP cyclique › Characterization of channel catfish (Ictalurus...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Characterization of channel catfish (Ictalurus...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › Extracellular Signal-Regulated MAP Kinases › Characterization of channel catfish (Ictalurus...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Characterization of channel catfish (Ictalurus...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Characterization of channel catfish (Ictalurus...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Characterization of channel catfish (Ictalurus...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Poissons-chats › Ictaluridae › Characterization of channel catfish (Ictalurus...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Characterization of channel catfish (Ictalurus...
questionsmedicales.fr › Sciences de l'information › Phylogenèse › Characterization of channel catfish (Ictalurus...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormone hypophysaire › Récepteur corticotrophine › Récepteurs à la mélanocortine › Récepteur de la mélanocortine de type 3 › Characterization of channel catfish (Ictalurus...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Characterization of channel catfish (Ictalurus...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Characterization of channel catfish (Ictalurus...
questionsmedicales.fr › Phénomènes génétiques › Similitude de séquences › Similitude de séquences d'acides nucléiques › Synténie › Characterization of channel catfish (Ictalurus...