CD44v3 and CD44v6 isoforms on T cells are able to discriminate different disease activity degrees and phenotypes in systemic lupus erythematosus patients.

Adult Case-Control Studies Disease Progression Female Flow Cytometry Gene Expression Genetic Markers Genetic Variation Humans Hyaluronan Receptors / genetics Lupus Erythematosus, Systemic / genetics Male Middle Aged Phenotype Severity of Illness Index T-Lymphocytes / immunology
CD44v3/v6 arthritis biomarkers disease activity nephritis systemic lupus erythematosus

Journal

Lupus
ISSN: 1477-0962
Titre abrégé: Lupus
Pays: England
ID NLM: 9204265

Informations de publication

Date de publication:
Apr 2019
Historique:
pubmed: 26 3 2019
medline: 30 11 2019
entrez: 26 3 2019
Statut: ppublish

Résumé

Adhesion molecule CD44 contributes to T cell migration into target organs. A higher expression of CD44v3 and v6 isoforms has been identified on T cells from systemic lupus erythematosus (SLE) patients. The aim of this study was to investigate the expression of CD44v3/v6 on T cells of SLE patients in order to evaluate their correlation with clinical features. Sixteen healthy subjects (HSs) and 33 SLE female patients were enrolled. Fifteen patients were in remission (Systemic Lupus Erythematosus Disease Activity Index-2000 (SLEDAI-2K) = 0) and 18 patients had an active disease (SLEDAI-2K ≥ 4). Experiments were conducted by flow cytometry. Expression of CD44v3 on CD4 CD44v3/v6 can be used as biomarkers of disease activity and phenotypes; isoform v6 on CD4

Sections du résumé

BACKGROUND BACKGROUND
Adhesion molecule CD44 contributes to T cell migration into target organs. A higher expression of CD44v3 and v6 isoforms has been identified on T cells from systemic lupus erythematosus (SLE) patients. The aim of this study was to investigate the expression of CD44v3/v6 on T cells of SLE patients in order to evaluate their correlation with clinical features.
METHODS METHODS
Sixteen healthy subjects (HSs) and 33 SLE female patients were enrolled. Fifteen patients were in remission (Systemic Lupus Erythematosus Disease Activity Index-2000 (SLEDAI-2K) = 0) and 18 patients had an active disease (SLEDAI-2K ≥ 4). Experiments were conducted by flow cytometry.
RESULTS RESULTS
Expression of CD44v3 on CD4
CONCLUSIONS CONCLUSIONS
CD44v3/v6 can be used as biomarkers of disease activity and phenotypes; isoform v6 on CD4

Identifiants

DOI: 10.1177/0961203319838063 PMID: 30907297
pubmed: 30907297
doi: 10.1177/0961203319838063
doi:

Substances chimiques

CD44 protein, human 0
Genetic Markers 0
Hyaluronan Receptors 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

621-628

Auteurs

L Novelli (L)

1 Lupus Clinic, Rheumatology Unit, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.
ORCID: 0000-0002-9639-0909

C Barbati (C)

1 Lupus Clinic, Rheumatology Unit, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.

F Ceccarelli (F)

1 Lupus Clinic, Rheumatology Unit, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.

C Perricone (C)

1 Lupus Clinic, Rheumatology Unit, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.

F R Spinelli (FR)

1 Lupus Clinic, Rheumatology Unit, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.

C Alessandri (C)

1 Lupus Clinic, Rheumatology Unit, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.

G Valesini (G)

1 Lupus Clinic, Rheumatology Unit, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.

R Perricone (R)

2 Rheumatology, Allergology and Clinical Immunology Unit, Department of "Medicina dei Sistemi", University of Rome Tor Vergata, Rome, Italy.

F Conti (F)

1 Lupus Clinic, Rheumatology Unit, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › CD44v3 and CD44v6 isoforms on T cells are able...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › CD44v3 and CD44v6 isoforms on T cells are able...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › CD44v3 and CD44v6 isoforms on T cells are able...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Cytophotométrie › Cytométrie en flux › CD44v3 and CD44v6 isoforms on T cells are able...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › CD44v3 and CD44v6 isoforms on T cells are able...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Marqueurs génétiques › CD44v3 and CD44v6 isoforms on T cells are able...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › CD44v3 and CD44v6 isoforms on T cells are able...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › CD44v3 and CD44v6 isoforms on T cells are able...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Récepteurs d'écotaxie des lymphocytes › Antigènes CD44 › CD44v3 and CD44v6 isoforms on T cells are able...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Lupus érythémateux disséminé › CD44v3 and CD44v6 isoforms on T cells are able...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › CD44v3 and CD44v6 isoforms on T cells are able...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › CD44v3 and CD44v6 isoforms on T cells are able...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › Indice de gravité de la maladie › CD44v3 and CD44v6 isoforms on T cells are able...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › CD44v3 and CD44v6 isoforms on T cells are able...