Yeast mitochondrial protein Pet111p binds directly to two distinct targets in
Cyclooxygenase 2
/ genetics
Membrane Proteins
/ genetics
Mitochondria
/ metabolism
Mitochondrial Proteins
/ genetics
Peptide Initiation Factors
/ genetics
Protein Binding
Protein Biosynthesis
RNA, Messenger
/ genetics
Recombinant Proteins
/ genetics
Saccharomyces cerevisiae
/ metabolism
Saccharomyces cerevisiae Proteins
/ genetics
PAR-CLIP
RNA–protein interaction
cytochrome c oxidase (Complex IV)
gene expression
mitochondria
pentatricopeptide repeat (PPR) protein
respiratory complex
translation regulation
translational activator
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
03 05 2019
03 05 2019
Historique:
received:
14
08
2018
revised:
10
03
2019
pubmed:
27
3
2019
medline:
8
1
2020
entrez:
27
3
2019
Statut:
ppublish
Résumé
The genes in mitochondrial DNA code for essential subunits of the respiratory chain complexes. In yeast, expression of mitochondrial genes is controlled by a group of gene-specific translational activators encoded in the nucleus. These factors appear to be part of a regulatory system that enables concerted expression of the necessary genes from both nuclear and mitochondrial genomes to produce functional respiratory complexes. Many of the translational activators are believed to act on the 5'-untranslated regions of target mRNAs, but the molecular mechanisms involved in this regulation remain obscure. In this study, we used a combination of
Identifiants
pubmed: 30910813
pii: S0021-9258(20)36824-1
doi: 10.1074/jbc.RA118.005355
pmc: PMC6509481
doi:
Substances chimiques
Membrane Proteins
0
Mitochondrial Proteins
0
PET111 protein, S cerevisiae
0
Peptide Initiation Factors
0
RNA, Messenger
0
Recombinant Proteins
0
Saccharomyces cerevisiae Proteins
0
Cyclooxygenase 2
EC 1.14.99.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7528-7536Informations de copyright
© 2019 Jones et al.
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