Studies of the Anti-amnesic Effects and Mechanisms of Single and Combined Use of Donepezil and Ginkgo Ketoester Tablet on Scopolamine-Induced Memory Impairment in Mice.
Acetylcholine
/ metabolism
Acetylcholinesterase
Amnesia
/ drug therapy
Animals
Benzothiazoles
/ chemistry
Biphenyl Compounds
/ chemistry
Brain-Derived Neurotrophic Factor
/ metabolism
Cholinesterase Inhibitors
/ pharmacology
Cognition Disorders
/ drug therapy
Donepezil
/ pharmacology
Drug Therapy, Combination
Ginkgo biloba
/ chemistry
Ginkgolides
/ chemistry
Ligands
Malondialdehyde
/ metabolism
Memory Disorders
/ chemically induced
Mice, Inbred ICR
Molecular Docking Simulation
Picrates
/ chemistry
Plant Extracts
/ pharmacology
Receptor, trkB
/ metabolism
Scopolamine
Sulfonic Acids
/ chemistry
Superoxide Dismutase
/ metabolism
Tablets
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2019
2019
Historique:
received:
10
09
2018
revised:
05
11
2018
accepted:
22
11
2018
entrez:
27
3
2019
pubmed:
27
3
2019
medline:
16
4
2019
Statut:
epublish
Résumé
Ginkgo ketoester tablets (GT) and donepezil were a clinically used combination for the treatment of Alzheimer's disease (AD). The aim of the study was undertaken to investigate the antiamnesic effects of the two drugs alone and in combination through
Identifiants
pubmed: 30911351
doi: 10.1155/2019/8636835
pmc: PMC6398023
doi:
Substances chimiques
Benzothiazoles
0
Biphenyl Compounds
0
Brain-Derived Neurotrophic Factor
0
Cholinesterase Inhibitors
0
Ginkgolides
0
Ligands
0
Picrates
0
Plant Extracts
0
Sulfonic Acids
0
Tablets
0
Ginkgo biloba extract
19FUJ2C58T
2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid
28752-68-3
Malondialdehyde
4Y8F71G49Q
Donepezil
8SSC91326P
1,1-diphenyl-2-picrylhydrazyl
DFD3H4VGDH
Scopolamine
DL48G20X8X
Superoxide Dismutase
EC 1.15.1.1
Receptor, trkB
EC 2.7.10.1
Acetylcholinesterase
EC 3.1.1.7
Acetylcholine
N9YNS0M02X
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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