Search for Novel Mutational Targets in Human Endocrine Diseases.


Journal

Endocrinology and metabolism (Seoul, Korea)
ISSN: 2093-5978
Titre abrégé: Endocrinol Metab (Seoul)
Pays: Korea (South)
ID NLM: 101554139

Informations de publication

Date de publication:
03 2019
Historique:
received: 22 12 2018
revised: 23 01 2019
accepted: 07 02 2019
entrez: 27 3 2019
pubmed: 27 3 2019
medline: 9 4 2020
Statut: ppublish

Résumé

The identification of disease-causing genetic variations is an important goal in the field of genetics. Advancements in genetic technology have changed scientific knowledge and made it possible to determine the basic mechanism and pathogenesis of human disorders rapidly. Many endocrine disorders are caused by genetic variations of a single gene or by mixed genetic factors. Various genetic testing methods are currently available, enabling a more precise diagnosis of many endocrine disorders and facilitating the development of a concrete therapeutic plan. In this review article, we discuss genetic testing technologies for genetic endocrine disorders, with relevant examples. We additionally describe our research on implementing genetic analysis strategies to identify novel causal mutations in hypocalcemia-related disorders.

Identifiants

pubmed: 30912335
pii: 34.23
doi: 10.3803/EnM.2019.34.1.23
pmc: PMC6435846
doi:

Types de publication

Comparative Study Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

23-28

Informations de copyright

Copyright © 2019 Korean Endocrine Society.

Déclaration de conflit d'intérêts

No potential conflict of interest relevant to this article was reported.

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Auteurs

So Young Park (SY)

Department of Internal Medicine, Cheil General Hospital & Women's Healthcare Center, Seoul, Korea.

Myeong Han Seo (MH)

Department of Internal Medicine and Laboratory of Genomics and Translational Medicine, Gachon University College of Medicine, Incheon, Korea.

Sihoon Lee (S)

Department of Internal Medicine and Laboratory of Genomics and Translational Medicine, Gachon University College of Medicine, Incheon, Korea. shleemd@gachon.ac.kr.

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Classifications MeSH