Genomic Signatures Predict the Immunogenicity of BRCA-Deficient Breast Cancer.

Antineoplastic Agents, Immunological / therapeutic use B7-H1 Antigen / antagonists & inhibitors BRCA1 Protein / genetics BRCA2 Protein / genetics Biomarkers, Tumor / genetics Breast Neoplasms / drug therapy CD8-Positive T-Lymphocytes / immunology Female Genomics / methods Homologous Recombination Humans

Journal

Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500

Informations de publication

Date de publication:
15 07 2019
Historique:
received: 15 02 2018
revised: 08 12 2018
accepted: 15 03 2019
pubmed: 28 3 2019
medline: 23 9 2020
entrez: 28 3 2019
Statut: ppublish

Résumé

Breast cancers with We hypothesized that genomic signatures might predict immunogenicity in We found that homologous recombination deficiency (HRD) scores were negatively associated with expression-based immune indices [cytolytic index ( HRD scores and hormone receptor subtype are predictive of immunogenicity in

Identifiants

DOI: 10.1158/1078-0432.CCR-18-0468 PMID: 30914433 PMC: PMC6635013
pubmed: 30914433
pii: 1078-0432.CCR-18-0468
doi: 10.1158/1078-0432.CCR-18-0468
pmc: PMC6635013
mid: NIHMS1525263
doi:

Substances chimiques

Antineoplastic Agents, Immunological 0
B7-H1 Antigen 0
BRCA1 Protein 0
BRCA1 protein, human 0
BRCA2 Protein 0
BRCA2 protein, human 0
Biomarkers, Tumor 0
CD274 protein, human 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4363-4374

Subventions

Organisme : NCI NIH HHS
ID : K08 CA215312
Pays : United States
Organisme : NCI NIH HHS
ID : K12 CA076931
Pays : United States
Organisme : NHGRI NIH HHS
ID : T32 HG009495
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016520
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR001880
Pays : United States

Informations de copyright

©2019 American Association for Cancer Research.

Références

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Auteurs

Adam A Kraya (AA)

Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Kara N Maxwell (KN)

Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Bradley Wubbenhorst (B)

Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Brandon M Wenz (BM)

Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

John Pluta (J)

Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Andrew J Rech (AJ)

Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Liza M Dorfman (LM)

Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Nicole Lunceford (N)

Division of Surgical Pathology, Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia Pennsylvania.

Amanda Barrett (A)

Division of Surgical Pathology, Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia Pennsylvania.

Nandita Mitra (N)

Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania.

Jennifer J D Morrissette (JJD)

Division of Precision and Computational Diagnostics, Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
ORCID: 0000-0001-9460-7177

Michael Feldman (M)

Division of Surgical Pathology, Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia Pennsylvania.
Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Anupma Nayak (A)

Division of Surgical Pathology, Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia Pennsylvania.

Susan M Domchek (SM)

Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Basser Center for BRCA, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Robert H Vonderheide (RH)

Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Basser Center for BRCA, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Katherine L Nathanson (KL)

Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. knathans@upenn.edu.
Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Basser Center for BRCA, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Antinéoplasiques immunologiques › Genomic Signatures Predict the Immunogenicity...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Antigènes B7 › Antigène CD274 › Genomic Signatures Predict the Immunogenicity...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéine BRCA1 › Genomic Signatures Predict the Immunogenicity...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéine BRCA2 › Genomic Signatures Predict the Immunogenicity...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Genomic Signatures Predict the Immunogenicity...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Genomic Signatures Predict the Immunogenicity...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Genomic Signatures Predict the Immunogenicity...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Genomic Signatures Predict the Immunogenicity...
questionsmedicales.fr › Phénomènes génétiques › Recombinaison génétique › Recombinaison homologue › Genomic Signatures Predict the Immunogenicity...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genomic Signatures Predict the Immunogenicity...