Effect of substituents on the configurational stability of the stereogenic nitrogen in metal(II) complexes of α-amino acid Schiff bases.
Schiff bases
amino acids
chiral HPLC
kinetic of racemization
metal(II) complexes
stereogenic nitrogen
Journal
Chirality
ISSN: 1520-636X
Titre abrégé: Chirality
Pays: United States
ID NLM: 8914261
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
31
01
2019
revised:
27
02
2019
accepted:
01
03
2019
pubmed:
28
3
2019
medline:
2
11
2019
entrez:
28
3
2019
Statut:
ppublish
Résumé
Herein, we report a general method for quantitative measurement of the configurational stability of the stereogenic nitrogen coordinated to M (II) in the corresponding square planar complexes. This stereochemical approach is quite sensitive to steric and electronic effects of the substituents and shown to work well for Ni(II), Pd(II), and Cu(II) complexes. Structural simplicity of the compounds used, coupled with high sensitivity and reliability of experimental procedures, bodes well for application of this approach in evaluation of chemical stability and stereochemical properties of newly designed chiral ligands for general asymmetric synthesis of tailor-made amino acids.
Substances chimiques
Amino Acids
0
Coordination Complexes
0
Ligands
0
Metals, Heavy
0
Schiff Bases
0
Nitrogen
N762921K75
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
401-409Subventions
Organisme : National Natural Science Foundation of China
ID : 21761132021
Pays : International
Informations de copyright
© 2019 Wiley Periodicals, Inc.