Aire-expressing ILC3-like cells in the lymph node display potent APC features.
Animals
Antigen-Presenting Cells
/ immunology
CD11 Antigens
/ metabolism
Epithelial Cell Adhesion Molecule
/ metabolism
Gene Expression Regulation
Histocompatibility Antigens Class II
/ metabolism
Immunity, Innate
Lymph Nodes
/ cytology
Lymphocytes
/ immunology
Mice
Mice, Inbred BALB C
Mice, Knockout
Nuclear Receptor Subfamily 1, Group F, Member 3
/ metabolism
Phenotype
Transcription Factors
/ genetics
Transcription, Genetic
AIRE Protein
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
06 05 2019
06 05 2019
Historique:
received:
27
07
2018
revised:
17
01
2019
accepted:
27
02
2019
pubmed:
29
3
2019
medline:
6
5
2020
entrez:
29
3
2019
Statut:
ppublish
Résumé
The autoimmune regulator (Aire) serves an essential function for T cell tolerance by promoting the "promiscuous" expression of tissue antigens in thymic epithelial cells. Aire is also detected in rare cells in peripheral lymphoid organs, but the identity of these cells is poorly understood. Here, we report that Aire protein-expressing cells in lymph nodes exhibit typical group 3 innate lymphoid cell (ILC3) characteristics such as lymphoid morphology, absence of "classical" hematopoietic lineage markers, and dependence on RORγt. Aire
Identifiants
pubmed: 30918005
pii: jem.20181430
doi: 10.1084/jem.20181430
pmc: PMC6504225
doi:
Substances chimiques
CD11 Antigens
0
Epithelial Cell Adhesion Molecule
0
Histocompatibility Antigens Class II
0
Itgax protein, mouse
0
Nuclear Receptor Subfamily 1, Group F, Member 3
0
Rorc protein, mouse
0
Transcription Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1027-1037Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2019 Yamano et al.
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