Structural effects of Diamond nanoparticles and Paclitaxel combination on calf thymus DNA.
Calf Thymus DNA (ct-DNA)
Nanodiamond (NDs)
Paclitaxel (PTX)
Spectroscopy
Journal
Nucleosides, nucleotides & nucleic acids
ISSN: 1532-2335
Titre abrégé: Nucleosides Nucleotides Nucleic Acids
Pays: United States
ID NLM: 100892832
Informations de publication
Date de publication:
2019
2019
Historique:
pubmed:
30
3
2019
medline:
28
11
2019
entrez:
30
3
2019
Statut:
ppublish
Résumé
The combination effects of nanodiamonds (NDs) and Paclitaxel (PTX) on the DNA structure were examined. The UV-Visible, steady-state and time-resolved fluorescence spectroscopy, CD, viscosity and zeta potential results showed that PTX + NDs could form a complex via groove binding mechanism. The values of binding constants, ΔG° and ΔH° and ΔS° values showed that PTX + NDs interact strongly with DNA and the hydrophobic force plays main role in this interaction. The
Identifiants
pubmed: 30922151
doi: 10.1080/15257770.2018.1515440
doi:
Substances chimiques
Diamond
7782-40-3
DNA
9007-49-2
calf thymus DNA
91080-16-9
Paclitaxel
P88XT4IS4D
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM