Review article: treatment options for functional dyspepsia.
Abdominal Pain
/ therapy
Anti-Infective Agents
/ therapeutic use
Complementary Therapies
/ methods
Dyspepsia
/ diagnosis
Gastritis
/ microbiology
Helicobacter Infections
/ complications
Helicobacter pylori
/ drug effects
Histamine H2 Antagonists
/ therapeutic use
Humans
Pain Management
/ methods
Phytotherapy
/ methods
Postprandial Period
/ drug effects
Proton Pump Inhibitors
/ therapeutic use
Journal
Alimentary pharmacology & therapeutics
ISSN: 1365-2036
Titre abrégé: Aliment Pharmacol Ther
Pays: England
ID NLM: 8707234
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
15
11
2018
revised:
03
12
2018
accepted:
23
01
2019
pubmed:
30
3
2019
medline:
14
4
2020
entrez:
30
3
2019
Statut:
ppublish
Résumé
Functional dyspepsia, consisting of epigastric pain syndrome and postprandial distress syndrome, is a prevalent functional gastrointestinal disorder. To date, only limited treatment options are available and conflicting results in terms of efficacy have been reported. Consequently, nonpharmacological treatment options are increasingly being explored for functional dyspepsia. To provide an overview of current pharmacological and nonpharmacological treatment options for functional dyspepsia. A literature search was conducted on Pubmed and other sources to identify relevant studies. Acid suppressive therapy reduced symptoms in 30%-70% of the patients, with higher benefit in epigastric pain syndrome and superior effectiveness for proton pump inhibitors compared to H None of the available therapies is effective in the majority of patients without being associated with major side effects. Developing new treatment options is challenging due to the heterogeneity of functional dyspepsia, the lack of readily identified target mechanisms and the poor association between pathophysiological disturbances and symptoms.
Sections du résumé
BACKGROUND
Functional dyspepsia, consisting of epigastric pain syndrome and postprandial distress syndrome, is a prevalent functional gastrointestinal disorder. To date, only limited treatment options are available and conflicting results in terms of efficacy have been reported. Consequently, nonpharmacological treatment options are increasingly being explored for functional dyspepsia.
AIM
To provide an overview of current pharmacological and nonpharmacological treatment options for functional dyspepsia.
METHODS
A literature search was conducted on Pubmed and other sources to identify relevant studies.
RESULTS
Acid suppressive therapy reduced symptoms in 30%-70% of the patients, with higher benefit in epigastric pain syndrome and superior effectiveness for proton pump inhibitors compared to H
CONCLUSIONS
None of the available therapies is effective in the majority of patients without being associated with major side effects. Developing new treatment options is challenging due to the heterogeneity of functional dyspepsia, the lack of readily identified target mechanisms and the poor association between pathophysiological disturbances and symptoms.
Substances chimiques
Anti-Infective Agents
0
Histamine H2 Antagonists
0
Proton Pump Inhibitors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1134-1172Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2019 John Wiley & Sons Ltd.