Volume not number of metastases: Gamma Knife radiosurgery management of intracranial lesions from an Australian perspective.
Brain metastases
Gamma knife surgery
Neurosurgery
Stereotactic radiosurgery
Stereotactic radiotherapy
Journal
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
ISSN: 1879-0887
Titre abrégé: Radiother Oncol
Pays: Ireland
ID NLM: 8407192
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
11
09
2018
revised:
31
10
2018
accepted:
17
12
2018
entrez:
3
4
2019
pubmed:
3
4
2019
medline:
6
2
2020
Statut:
ppublish
Résumé
To assess the response of the first cohort of patients treated with Gamma Knife radiosurgery in Australia. A prospectively collected cohort of 180 patients with intracranial metastases from different primaries was treated between August 2010 and July 2017. Survival was calculated using the Kaplan-Meier's method. Cox regression was used for multivariate analysis. Currently 141 patients (78.3%) have died of their disease. The median survival for the group as a whole was 9.2 months, with observed differences resulting from the volume of tumor burden (11.4 months for volumes <3.2 cm Results from the first Gamma Knife radiosurgery center in Australia showed that the treatment is feasible and effective, consistent with the international experience. For patients with larger numbers of intracranial metastases, the total volume of the intracranial burden may be of more significance in predicting outcomes. While there appeared to be a difference in survival by histologic origin, this could be related to concurrent systemic immunotherapy available for certain tumors.
Sections du résumé
BACKGROUND AND PURPOSE
To assess the response of the first cohort of patients treated with Gamma Knife radiosurgery in Australia.
MATERIALS AND METHODS
A prospectively collected cohort of 180 patients with intracranial metastases from different primaries was treated between August 2010 and July 2017. Survival was calculated using the Kaplan-Meier's method. Cox regression was used for multivariate analysis.
RESULTS
Currently 141 patients (78.3%) have died of their disease. The median survival for the group as a whole was 9.2 months, with observed differences resulting from the volume of tumor burden (11.4 months for volumes <3.2 cm
CONCLUSION
Results from the first Gamma Knife radiosurgery center in Australia showed that the treatment is feasible and effective, consistent with the international experience. For patients with larger numbers of intracranial metastases, the total volume of the intracranial burden may be of more significance in predicting outcomes. While there appeared to be a difference in survival by histologic origin, this could be related to concurrent systemic immunotherapy available for certain tumors.
Identifiants
pubmed: 30935580
pii: S0167-8140(18)33657-0
doi: 10.1016/j.radonc.2018.12.018
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
43-49Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.