DNA methylation inhibitor attenuates polyglutamine-induced neurodegeneration by regulating Hes5.
Aged
Animals
Basic Helix-Loop-Helix Transcription Factors
/ metabolism
Cell Survival
/ drug effects
DNA (Cytosine-5-)-Methyltransferase 1
/ metabolism
DNA Methylation
Humans
Mice, Inbred C57BL
Middle Aged
Models, Biological
Motor Activity
/ drug effects
Motor Neurons
/ drug effects
Muscular Atrophy, Spinal
/ pathology
Nerve Degeneration
/ metabolism
Peptides
/ toxicity
Phthalimides
/ pharmacology
Promoter Regions, Genetic
/ genetics
Receptors, Androgen
/ metabolism
Repressor Proteins
/ metabolism
Smad2 Protein
/ metabolism
Spinal Cord
/ pathology
Tryptophan
/ analogs & derivatives
DNA methylation
Hes5
RG108
epigenetics
spinal and bulbar muscular atrophy
Journal
EMBO molecular medicine
ISSN: 1757-4684
Titre abrégé: EMBO Mol Med
Pays: England
ID NLM: 101487380
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
pubmed:
4
4
2019
medline:
28
4
2020
entrez:
4
4
2019
Statut:
ppublish
Résumé
Spinal and bulbar muscular atrophy (SBMA) is a polyglutamine-mediated neuromuscular disease caused by a CAG repeat expansion in the
Identifiants
pubmed: 30940675
pii: emmm.201708547
doi: 10.15252/emmm.201708547
pmc: PMC6505579
pii:
doi:
Substances chimiques
Basic Helix-Loop-Helix Transcription Factors
0
Hes5 protein, mouse
0
Peptides
0
Phthalimides
0
RG108
0
Receptors, Androgen
0
Repressor Proteins
0
Smad2 Protein
0
polyglutamine
26700-71-0
Tryptophan
8DUH1N11BX
DNA (Cytosine-5-)-Methyltransferase 1
EC 2.1.1.37
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2019 The Authors. Published under the terms of the CC BY 4.0 license.
Références
Lancet Oncol. 2009 Mar;10(3):223-32
pubmed: 19230772
Cell Mol Biol Lett. 2012 Dec;17(4):501-25
pubmed: 22820861
Adv Exp Med Biol. 2017;978:277-299
pubmed: 28523552
Cell Rep. 2014 May 8;7(3):774-84
pubmed: 24746732
Lancet Neurol. 2010 Sep;9(9):875-84
pubmed: 20691641
Haematologica. 2013 Jul;98(7):1067-72
pubmed: 23585522
J Neurosci. 2010 Apr 21;30(16):5702-12
pubmed: 20410122
Cell. 2007 Feb 23;128(4):683-92
pubmed: 17320506
Oncotarget. 2015 Jan 20;6(2):746-54
pubmed: 25481873
Brain. 1989 Feb;112 ( Pt 1):209-32
pubmed: 2917278
Nat Commun. 2013;4:1405
pubmed: 23360996
Hum Mol Genet. 2015 Nov 1;24(21):5985-94
pubmed: 26231218
Brain. 2005 Mar;128(Pt 3):659-70
pubmed: 15659427
Dev Growth Differ. 2008 Jun;50 Suppl 1:S97-103
pubmed: 18430159
Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):E3027-36
pubmed: 23872847
Hum Mol Genet. 2015 Jan 15;24(2):314-29
pubmed: 25168383
Hum Mol Genet. 2004 Jun 1;13(11):1183-92
pubmed: 15102712
Prog Neurobiol. 2012 Dec;99(3):246-56
pubmed: 22609045
Arch Neurol. 2012 Apr;69(4):436-40
pubmed: 22158719
J Huntingtons Dis. 2013;2(3):263-77
pubmed: 25062675
Cell Mol Life Sci. 2016 Nov;73(21):3991-9
pubmed: 27188284
Sci Rep. 2013 Nov 14;3:3219
pubmed: 24225777
Neuron. 2002 Aug 29;35(5):843-54
pubmed: 12372280
Nat Rev Genet. 2006 Jun;7(6):415-26
pubmed: 16708070
J Neurosci. 2010 Mar 3;30(9):3489-98
pubmed: 20203209
Pediatr Res. 2007 May;61(5 Pt 2):58R-63R
pubmed: 17413844
J Mol Neurosci. 2016 Mar;58(3):365-73
pubmed: 26614347
J Mol Neurosci. 2016 Mar;58(3):317-20
pubmed: 26547319
Nat Med. 2003 Jun;9(6):768-73
pubmed: 12754502
J Mol Neurosci. 2016 Mar;58(3):348-64
pubmed: 26572535
Nat Neurosci. 2014 Sep;17(9):1156-63
pubmed: 25129075
Brain. 2006 Jun;129(Pt 6):1446-55
pubmed: 16621916
J Neurosci. 2011 Nov 16;31(46):16619-36
pubmed: 22090490
Nature. 2006 Jan 26;439(7075):430-6
pubmed: 16437107
Neurology. 1968 Jul;18(7):671-80
pubmed: 4233749
Nature. 2012 Jul 18;487(7407):330-7
pubmed: 22810696
Neuropharmacology. 2014 May;80:95-102
pubmed: 24486385
Curr Pharm Des. 2014;20(11):1803-11
pubmed: 23888969
Trends Genet. 2003 May;19(5):233-8
pubmed: 12711212
Nat Rev Neurosci. 2006 Oct;7(10):784-96
pubmed: 16988654
Cell Res. 1999 Sep;9(3):179-88
pubmed: 10520600
Cancer Res. 2005 Jul 15;65(14):6305-11
pubmed: 16024632
CA Cancer J Clin. 2015 Mar;65(2):87-108
pubmed: 25651787
J Mol Neurosci. 2016 Mar;58(3):321-9
pubmed: 26482145
Nat Rev Genet. 2013 Mar;14(3):204-20
pubmed: 23400093
Neurochem Int. 2018 Oct;119:17-25
pubmed: 28627366
Transl Psychiatry. 2016 Jan 19;6:e718
pubmed: 26784972
Nat Rev Genet. 2007 Apr;8(4):286-98
pubmed: 17339880
Sci Rep. 2016 Aug 12;6:31022
pubmed: 27516062
Dev Neurosci. 2006;28(1-2):92-101
pubmed: 16508307
Cancer Sci. 2013 Dec;104(12):1575-85
pubmed: 24118411
Neuromolecular Med. 2014 Jun;16(2):231-64
pubmed: 24615633
Nat Clin Pract Neurol. 2006 Jun;2(6):330-8
pubmed: 16932577
Nat Rev Neurosci. 2010 Jun;11(6):377-88
pubmed: 20485363
Development. 2004 Nov;131(22):5539-50
pubmed: 15496443
Nat Med. 2012 Oct;18(10):1531-8
pubmed: 23023499
Nat Med. 2012 Jul;18(7):1136-41
pubmed: 22660636
Neuron. 2014 Apr 16;82(2):295-307
pubmed: 24742458
Epigenetics. 2011 May;6(5):638-49
pubmed: 21593597