Location is the key to function: HMGB1 in sepsis and trauma-induced inflammation.
AIM2
DAMPs
autophagy
caspase-11
pyroptosis
Journal
Journal of leukocyte biology
ISSN: 1938-3673
Titre abrégé: J Leukoc Biol
Pays: England
ID NLM: 8405628
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
20
12
2018
revised:
18
02
2019
accepted:
04
03
2019
pubmed:
5
4
2019
medline:
12
5
2020
entrez:
5
4
2019
Statut:
ppublish
Résumé
High mobility group box 1 (HMGB1) is a multifunctional nuclear protein, probably known best as a prototypical alarmin or damage-associated molecular pattern (DAMP) molecule when released from cells. However, HMGB1 has multiple functions that depend on its location in the nucleus, in the cytosol, or extracellularly after either active release from cells, or passive release upon lytic cell death. Movement of HMGB1 between cellular compartments is a dynamic process induced by a variety of cell stresses and disease processes, including sepsis, trauma, and hemorrhagic shock. Location of HMGB1 is intricately linked with its function and is regulated by a series of posttranslational modifications. HMGB1 function is also regulated by the redox status of critical cysteine residues within the protein, and is cell-type dependent. This review highlights some of the mechanisms that contribute to location and functions of HMGB1, and focuses on some recent insights on important intracellular effects of HMGB1 during sepsis and trauma.
Identifiants
pubmed: 30946496
doi: 10.1002/JLB.3MIR1218-497R
pmc: PMC6597316
mid: NIHMS1015962
doi:
Substances chimiques
Alarmins
0
HMGB1 Protein
0
Inflammasomes
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
161-169Subventions
Organisme : BLRD VA
ID : IK6 BX004211
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL076179
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL079669
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM050441
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139547
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM102146
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM127027
Pays : United States
Organisme : BLRD VA
ID : I01 BX002729
Pays : United States
Informations de copyright
©2019 Society for Leukocyte Biology.
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