exRNA Atlas Analysis Reveals Distinct Extracellular RNA Cargo Types and Their Carriers Present across Human Biofluids.
ERCC
deconvolution
exRNA
exosomes
extracellular RNA
extracellular vesicles
lipoproteins
ribonucleoproteins
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
04 04 2019
04 04 2019
Historique:
received:
28
04
2018
revised:
06
11
2018
accepted:
11
02
2019
entrez:
6
4
2019
pubmed:
6
4
2019
medline:
25
1
2020
Statut:
ppublish
Résumé
To develop a map of cell-cell communication mediated by extracellular RNA (exRNA), the NIH Extracellular RNA Communication Consortium created the exRNA Atlas resource (https://exrna-atlas.org). The Atlas version 4P1 hosts 5,309 exRNA-seq and exRNA qPCR profiles from 19 studies and a suite of analysis and visualization tools. To analyze variation between profiles, we apply computational deconvolution. The analysis leads to a model with six exRNA cargo types (CT1, CT2, CT3A, CT3B, CT3C, CT4), each detectable in multiple biofluids (serum, plasma, CSF, saliva, urine). Five of the cargo types associate with known vesicular and non-vesicular (lipoprotein and ribonucleoprotein) exRNA carriers. To validate utility of this model, we re-analyze an exercise response study by deconvolution to identify physiologically relevant response pathways that were not detected previously. To enable wide application of this model, as part of the exRNA Atlas resource, we provide tools for deconvolution and analysis of user-provided case-control studies.
Identifiants
pubmed: 30951672
pii: S0092-8674(19)30167-9
doi: 10.1016/j.cell.2019.02.018
pmc: PMC6616370
mid: NIHMS1521746
pii:
doi:
Substances chimiques
Cell-Free Nucleic Acids
0
Circulating MicroRNA
0
RNA
63231-63-0
Types de publication
Dataset
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
463-477.e15Subventions
Organisme : NIA NIH HHS
ID : R01 AG059729
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL122547
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK063720
Pays : United States
Organisme : NCATS NIH HHS
ID : UH3 TR000906
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA217685
Pays : United States
Organisme : NCATS NIH HHS
ID : UH2 TR000906
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA209904
Pays : United States
Organisme : NCATS NIH HHS
ID : UH2 TR000923
Pays : United States
Organisme : NCATS NIH HHS
ID : UH3 TR000943
Pays : United States
Organisme : NIDA NIH HHS
ID : U54 DA036134
Pays : United States
Organisme : NCATS NIH HHS
ID : UH3 TR000891
Pays : United States
Organisme : NCATS NIH HHS
ID : UH3 TR000901
Pays : United States
Organisme : NCATS NIH HHS
ID : UH3 TR000923
Pays : United States
Organisme : NCATS NIH HHS
ID : UH2 TR000901
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL127099
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL133575
Pays : United States
Organisme : NIGMS NIH HHS
ID : R25 GM056929
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL136685
Pays : United States
Organisme : NCI NIH HHS
ID : U19 CA179512
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008307
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL126494
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA163849
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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