Rhinovirus infections in infants suggest that early detection can prevent unnecessary treatment.
Acute Disease
/ epidemiology
Child, Preschool
Female
Hospitalization
Humans
Infant
Infant, Newborn
Israel
/ epidemiology
Male
Picornaviridae Infections
/ diagnosis
Real-Time Polymerase Chain Reaction
Respiratory Tract Infections
/ diagnosis
Retrospective Studies
Rhinovirus
/ classification
Risk Factors
Sequence Analysis, RNA
Serogroup
Hospitalized
Influenza-like illness
Respiratory
Rhinovirus
Journal
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
ISSN: 1873-5967
Titre abrégé: J Clin Virol
Pays: Netherlands
ID NLM: 9815671
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
11
07
2018
revised:
15
12
2018
accepted:
20
03
2019
pubmed:
6
4
2019
medline:
21
5
2020
entrez:
6
4
2019
Statut:
ppublish
Résumé
Human rhinoviruses (hRV) are small, RNA viruses of the Picornaviridae family, which are divided into three subtypes (A, B, C). hRVs are among the most common causes for acute respiratory illnesses (ARI) involving both the upper and lower respiratory tract. This study aimed to assess the magnitude and characteristics of hRV infections in hospitalized children, aged less than 5 years, hospitalized in Israel during 2011-2012. The 2503 respiratory samples were subjected to real-time PCR, to detect hRV and other respiratory viruses. Rhinovirus-positive samples were further tested by sequencing to identify the infecting species. Of these 2503 respiratory samples, 422 tested positive for hRV, of them, 243 were from children under 5 years of age (58% of all rhinoviral-positive samples). We also found that among the ARI-associated hospital admissions, 16% were positive for rhinovirus. hRV type A was the most common species. Laboratory data showed monocytosis in 51%, hypercalcemia in 61% and lower respiratory tract involvement in 75% of patients. We thus recommend including rhinovirus testing as part of the routine testing performed in young children presenting with ARI.
Sections du résumé
BACKGROUND
Human rhinoviruses (hRV) are small, RNA viruses of the Picornaviridae family, which are divided into three subtypes (A, B, C). hRVs are among the most common causes for acute respiratory illnesses (ARI) involving both the upper and lower respiratory tract.
OBJECTIVES
This study aimed to assess the magnitude and characteristics of hRV infections in hospitalized children, aged less than 5 years, hospitalized in Israel during 2011-2012.
STUDY DESIGN
The 2503 respiratory samples were subjected to real-time PCR, to detect hRV and other respiratory viruses. Rhinovirus-positive samples were further tested by sequencing to identify the infecting species.
RESULTS
Of these 2503 respiratory samples, 422 tested positive for hRV, of them, 243 were from children under 5 years of age (58% of all rhinoviral-positive samples). We also found that among the ARI-associated hospital admissions, 16% were positive for rhinovirus. hRV type A was the most common species. Laboratory data showed monocytosis in 51%, hypercalcemia in 61% and lower respiratory tract involvement in 75% of patients.
CONCLUSIONS
We thus recommend including rhinovirus testing as part of the routine testing performed in young children presenting with ARI.
Identifiants
pubmed: 30952067
pii: S1386-6532(19)30068-X
doi: 10.1016/j.jcv.2019.03.012
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
11-17Informations de copyright
Copyright © 2019. Published by Elsevier B.V.