Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8
Animals
CD8-Positive T-Lymphocytes
/ immunology
Cell Proliferation
Cells, Cultured
Cytokines
/ biosynthesis
Endoplasmic Reticulum Stress
/ genetics
Female
Hereditary Sensory and Autonomic Neuropathies
/ genetics
Humans
Lymphocytic Choriomeningitis
/ immunology
Lymphocytic choriomeningitis virus
/ immunology
Male
Mechanistic Target of Rapamycin Complex 1
/ metabolism
Mice
Mice, Inbred C57BL
Middle Aged
Serine C-Palmitoyltransferase
/ genetics
Signal Transduction
/ immunology
Sphingolipids
/ biosynthesis
CD8+ T cells
ER stress
HSAN-I
SPTLC2
neurological diseases
Journal
Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918
Informations de publication
Date de publication:
21 05 2019
21 05 2019
Historique:
received:
20
04
2018
revised:
07
01
2019
accepted:
06
03
2019
pubmed:
7
4
2019
medline:
18
10
2019
entrez:
7
4
2019
Statut:
ppublish
Résumé
Patients with the neurological disorder HSAN-I suffer frequent infections, attributed to a lack of pain sensation and failure to seek care for minor injuries. Whether protective CD8
Identifiants
pubmed: 30952607
pii: S1074-7613(19)30095-0
doi: 10.1016/j.immuni.2019.03.005
pmc: PMC6531359
mid: NIHMS1523939
pii:
doi:
Substances chimiques
Cytokines
0
Sphingolipids
0
SPTLC2 protein, human
EC 2.3.1.50
Serine C-Palmitoyltransferase
EC 2.3.1.50
Mechanistic Target of Rapamycin Complex 1
EC 2.7.11.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1218-1231.e5Subventions
Organisme : Austrian Science Fund FWF
ID : P 27634
Pays : Austria
Organisme : NCATS NIH HHS
ID : UL1 TR001442
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
Références
J Lipid Res. 2017 Jan;58(1):42-59
pubmed: 27881717
J Biol Chem. 2001 Jun 8;276(23):20589-96
pubmed: 11279185
J Gen Virol. 1983 Aug;64 (Pt 8):1689-98
pubmed: 6875516
Nature. 2013 Jul 25;499(7459):485-90
pubmed: 23812589
Nature. 2017 Jun 1;546(7656):158-161
pubmed: 28538737
Sci Rep. 2017 Nov 14;7(1):15552
pubmed: 29138469
Immunity. 2011 Dec 23;35(6):871-82
pubmed: 22195744
Cell Death Dis. 2018 Feb 7;9(2):173
pubmed: 29415989
Nature. 1996 Jun 27;381(6585):800-3
pubmed: 8657285
Science. 2005 Feb 11;307(5711):935-9
pubmed: 15705855
J Biol Chem. 2012 May 25;287(22):18429-39
pubmed: 22493506
Cell. 2012 Apr 13;149(2):274-93
pubmed: 22500797
Bioinformatics. 2014 Apr 1;30(7):923-30
pubmed: 24227677
J Biol Chem. 2001 Jun 29;276(26):23954-61
pubmed: 11287428
Cell Signal. 2008 Jun;20(6):1010-8
pubmed: 18191382
Genes Dev. 1996 Feb 15;10(4):382-94
pubmed: 8600023
J Exp Med. 2018 Mar 5;215(3):985-997
pubmed: 29436394
J Biol Chem. 2002 Jul 26;277(30):26796-803
pubmed: 12006562
Nature. 1998 Jun 4;393(6684):478-80
pubmed: 9624004
Circ Res. 2001 Sep 14;89(6):496-502
pubmed: 11557736
Annu Rev Med. 1996;47:229-39
pubmed: 8712778
PLoS One. 2012;7(10):e47004
pubmed: 23071696
Am J Hum Genet. 2010 Oct 8;87(4):513-22
pubmed: 20920666
Diabetes. 2017 Oct;66(10):2596-2609
pubmed: 28698261
J Biol Chem. 1997 Jan 31;272(5):3064-72
pubmed: 9006957
Genome Biol. 2014;15(12):550
pubmed: 25516281
FASEB J. 2009 Mar;23(3):751-63
pubmed: 19028839
Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5201-6
pubmed: 18362335
J Clin Invest. 2013 Apr;123(4):1784-97
pubmed: 23549085
Nature. 1989 Nov 30;342(6249):559-61
pubmed: 2573841
Immunity. 2007 Aug;27(2):281-95
pubmed: 17723218
Curr Opin Cell Biol. 2015 Apr;33:55-66
pubmed: 25554914
J Biol Chem. 1999 Jul 16;274(29):20313-7
pubmed: 10400653
J Exp Med. 1995 Aug 1;182(2):367-77
pubmed: 7629499
Endocrinology. 2002 Dec;143(12):4755-63
pubmed: 12446603
Nat Immunol. 2009 Jul;10(7):761-8
pubmed: 19525969
Nature. 1998 Jun 4;393(6684):474-8
pubmed: 9624003
J Neurosci. 2009 May 6;29(18):5926-37
pubmed: 19420259
Nat Rev Mol Cell Biol. 2008 Feb;9(2):139-50
pubmed: 18216770
Nat Immunol. 2010 Nov;11(11):1047-56
pubmed: 20852647
Nat Rev Immunol. 2008 Oct;8(10):753-63
pubmed: 18787560
J Exp Med. 1996 Dec 1;184(6):2411-6
pubmed: 8976196
Biochimie. 2003 Mar-Apr;85(3-4):423-37
pubmed: 12770781
J Clin Invest. 2011 Dec;121(12):4735-45
pubmed: 22045570
Biochemistry. 2000 Jun 6;39(22):6660-8
pubmed: 10828984
J Exp Med. 2012 Dec 17;209(13):2441-53
pubmed: 23183047
Hepatology. 1997 Apr;25(4):958-63
pubmed: 9096604
J Biol Chem. 2009 Sep 25;284(39):27010-9
pubmed: 19648608
Nat Immunol. 2009 Jul;10(7):769-77
pubmed: 19483717
J Biol Chem. 2010 Apr 9;285(15):11178-87
pubmed: 20097765
Blood. 2003 Jun 15;101(12):4909-15
pubmed: 12586615
Jpn J Cancer Res. 1993 Nov;84(11):inside front cover
pubmed: 8276711
Mol Cell. 2010 May 28;38(4):576-89
pubmed: 20513432
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Nat Genet. 2001 Mar;27(3):261-2
pubmed: 11242106
Nat Genet. 2001 Mar;27(3):309-12
pubmed: 11242114
Mol Cell. 2008 Mar 14;29(5):541-51
pubmed: 18342602
J Immunol. 2007 Apr 1;178(7):4112-9
pubmed: 17371966
Cell. 1994 Jun 17;77(6):917-29
pubmed: 8004678
Mitochondrion. 2006 Jun;6(3):118-25
pubmed: 16713754
Nature. 2004 Jan 22;427(6972):355-60
pubmed: 14737169
J Biol Chem. 2008 Sep 5;283(36):24707-17
pubmed: 18596045
J Immunol. 2008 Dec 1;181(11):7445-8
pubmed: 19017930
Nat Immunol. 2016 May;17(5):556-64
pubmed: 26974206
J Exp Med. 1997 Jul 7;186(1):65-70
pubmed: 9206998
Immunol Rev. 2004 Dec;202:67-83
pubmed: 15546386
N Engl J Med. 2010 Feb 4;362(5):387-401
pubmed: 20089952
J Biol Chem. 1999 Mar 5;274(10):6080-4
pubmed: 10037689
J Biol Chem. 1993 Jul 25;268(21):15523-30
pubmed: 8393446
J Biol Chem. 1996 May 10;271(19):11059-62
pubmed: 8626647
Immunity. 2001 Nov;15(5):763-74
pubmed: 11728338
Nature. 1998 Jun 4;393(6684):480-3
pubmed: 9624005
Annu Rev Immunol. 2012;30:69-94
pubmed: 22149932
Neurology. 2013 Jun 4;80(23):2106-11
pubmed: 23658386
JCI Insight. 2017 May 18;2(10):
pubmed: 28515365