Roger Sandhoff

Affiliations

Lipid Pathobiochemistry Group, German Cancer Research Center, Heidelberg, Germany; Center for Applied Research in Biomedical Mass Spectrometry (ABIMAS), Mannheim, Germany. Electronic address: r.sandhoff@dkfz.de.

Publications (27)

Endogenous levels of 1-O-acylceramides increase upon acidic ceramidase deficiency and decrease due to loss of Dgat1 in a tissue-dependent manner.

Biochimica et biophysica acta. Molecular and cell biology of lipids

Avec: Aline Bayerle , Christian Marsching , Mariona Rabionet , Shaalee Dworski , Mustafa A Kamani , Chandramohan Chitraju , Nina L Gluchowski , Katlyn R Gabriel , Silke Herzer , Richard Jennemann , Thierry Levade , Jeffrey A Medin , Roger Sandhoff

Blockade of Glycosphingolipid Synthesis Inhibits Cell Cycle and Spheroid Growth of Colon Cancer Cells In Vitro and Experimental Colon Cancer Incidence In Vivo.

International journal of molecular sciences

Avec: Richard Jennemann , Martina Volz , Felix Bestvater , Claudia Schmidt , Karsten Richter , Sylvia Kaden , Johannes Müthing , Hermann-Josef Gröne , Roger Sandhoff

Epidermal 1-O-acylceramides appear with the establishment of the water permeability barrier in mice and are produced by maturating keratinocytes.

Lipids

Avec: Mariona Rabionet , Pauline Bernard , Melanie Pichery , Christian Marsching , Aline Bayerle , Shaalee Dworski , Mustafa A Kamani , Chandramohan Chitraju , Nina L Gluchowski , Katlyn R Gabriel , Abolfazl Asadi , Philipp Ebel , Menno Hoekstra , Sabrina Dumas , James M Ntambi , Anders Jacobsson , Klaus Willecke , Jeffrey A Medin , Nathalie Jonca , Roger Sandhoff

CNS myelin protein 36K regulates oligodendrocyte differentiation through Notch.

Glia

Avec: Bhuvaneswari Nagarajan , Alexander Harder , Anna Japp , Felix Häberlein , Enrico Mingardo , Henning Kleinert , Öznur Yilmaz , Angelika Zoons , Birgit Rau , Andrea Christ , Ulrich Kubitscheck , Britta Eiberger , Roger Sandhoff , Matthias Eckhardt , Dieter Hartmann , Benjamin Odermatt

Renal globotriaosylceramide facilitates tubular albumin absorption and its inhibition protects against acute kidney injury.

Kidney international

Avec: Ivan Morace , Robert Pilz , Giuseppina Federico , Richard Jennemann , Damir Krunic , Viola Nordström , Johanna von Gerichten , Christian Marsching , Ina Maria Schießl , Johannes Müthing , Christian Wunder , Ludger Johannes , Roger Sandhoff , Hermann-Josef Gröne

Formation of keto-type ceramides in palmoplantar keratoderma based on biallelic KDSR mutations in patients.

Human molecular genetics

Avec: Robert Pilz , Lukáš Opálka , Adam Majcher , Elisabeth Grimm , Lionel Van Maldergem , Silvia Mihalceanu , Knut Schäkel , Alexander Enk , François Aubin , Anne-Claire Bursztejn , Elise Brischoux-Boucher , Judith Fischer , Roger Sandhoff

Sphinganine recruits TLR4 adaptors in macrophages and promotes inflammation in murine models of sepsis and melanoma.

Nature communications

Avec: Marvin Hering , Alaa Madi , Roger Sandhoff , Sicong Ma , Jingxia Wu , Alessa Mieg , Karsten Richter , Kerstin Mohr , Nora Knabe , Diana Stichling , Gernot Poschet , Felix Bestvater , Larissa Frank , Jochen Utikal , Viktor Umansky , Guoliang Cui

Serine enrichment in tumors promotes regulatory T cell accumulation through sphinganine-mediated regulation of c-Fos.

Science immunology

Avec: Sicong Ma , Roger Sandhoff , Xiu Luo , Fuwei Shang , Qiaozhen Shi , Zhaolong Li , Jingxia Wu , Yanan Ming , Frank Schwarz , Alaa Madi , Nina Weisshaar , Alessa Mieg , Marvin Hering , Ferdinand Zettl , Xin Yan , Kerstin Mohr , Nora Ten Bosch , Zhe Li , Gernot Poschet , Hans-Reimer Rodewald , Nina Papavasiliou , Xi Wang , Pu Gao , Guoliang Cui

Sphingosine-1-Phosphate Recruits Macrophages and Microglia and Induces a Pro-Tumorigenic Phenotype That Favors Glioma Progression.

Cancers

Avec: Lavinia Arseni , Rakesh Sharma , Norman Mack , Deepthi Nagalla , Sibylle Ohl , Thomas Hielscher , Mahak Singhal , Robert Pilz , Hellmut Augustin , Roger Sandhoff , Christel Herold-Mende , Björn Tews , Peter Lichter , Martina Seiffert

GD2 Expression in Medulloblastoma and Neuroblastoma for Personalized Immunotherapy: A Matter of Subtype.

Cancers

Avec: Claudia Paret , Arsenij Ustjanzew , Sara Ersali , Larissa Seidmann , Richard Jennemann , Nicole Ziegler , Khalifa El Malki , Alexandra Russo , Arthur Wingerter , Franziska Ortmüller , Angelina Bornas , Pia Charlotte Wehling , Adina Lepădatu , Malte Ottenhausen , Wilfried Roth , Clemens Sommer , Barbara Fliss , Katrin B M Frauenknecht , Roger Sandhoff , Jörg Faber

Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8

Immunity

Avec: Jingxia Wu , Sicong Ma , Roger Sandhoff , Yanan Ming , Agnes Hotz-Wagenblatt , Vincent Timmerman , Nathalie Bonello-Palot , Beate Schlotter-Weigel , Michaela Auer-Grumbach , Pavel Seeman , Wolfgang N Löscher , Markus Reindl , Florian Weiss , Eric Mah , Nina Weisshaar , Alaa Madi , Kerstin Mohr , Tilo Schlimbach , Rubí M-H Velasco Cárdenas , Jonas Koeppel , Florian Grünschläger , Lisann Müller , Maren Baumeister , Britta Brügger , Michael Schmitt , Guido Wabnitz , Yvonne Samstag , Guoliang Cui

Species-specific differences in nonlysosomal glucosylceramidase GBA2 function underlie locomotor dysfunction arising from loss-of-function mutations.

The Journal of biological chemistry

Avec: Marina A Woeste , Sina Stern , Diana N Raju , Elena Grahn , Dominik Dittmann , Katharina Gutbrod , Peter Dörmann , Jan N Hansen , Sophie Schonauer , Carina E Marx , Hussein Hamzeh , Heinz G Körschen , Johannes M F G Aerts , Wolfgang Bönigk , Heike Endepols , Roger Sandhoff , Matthias Geyer , Thomas K Berger , Frank Bradke , Dagmar Wachten

Neuronal Ganglioside and Glycosphingolipid (GSL) Metabolism and Disease : Cascades of Secondary Metabolic Errors Can Generate Complex Pathologies (in LSDs).

Advances in neurobiology

Avec: Roger Sandhoff , Konrad Sandhoff

Unraveling the glycosphingolipid metabolism by leveraging transcriptome-weighted network analysis on neuroblastic tumors.

Cancer & metabolism

Avec: Arsenij Ustjanzew , Annekathrin Silvia Nedwed , Roger Sandhoff , Jörg Faber , Federico Marini , Claudia Paret

Effect of Increased Lactate Dehydrogenase A Activity and Aerobic Glycolysis on the Proinflammatory Profile of Autoimmune CD8+ T Cells in Rheumatoid Arthritis.

Arthritis & rheumatology (Hoboken, N.J.)

Avec: M Margarida Souto-Carneiro , Karel D Klika , Mónica T Abreu , André P Meyer , Rainer Saffrich , Roger Sandhoff , Richard Jennemann , Franziska V Kraus , Lars Tykocinski , Volker Eckstein , Lina Carvalho , Mark Kriegsmann , Thomas Giese , Hanns-Martin Lorenz , Rui A Carvalho

Identification of

Journal of the American Society of Nephrology : JASN

Avec: Theun de Groot , Lena K Ebert , Birgitte Mønster Christensen , Karolina Andralojc , Lydie Cheval , Alain Doucet , Cungui Mao , Ruben Baumgarten , Benjamin E Low , Roger Sandhoff , Michael V Wiles , Peter M T Deen , Ron Korstanje

Tumor Lipids of Pediatric Papillary Renal Cell Carcinoma Stimulate Unconventional T Cells.

Frontiers in immunology

Avec: Nadine Lehmann , Claudia Paret , Khalifa El Malki , Alexandra Russo , Marie Astrid Neu , Arthur Wingerter , Larissa Seidmann , Sebastian Foersch , Nicole Ziegler , Lea Roth , Nora Backes , Roger Sandhoff , Joerg Faber

Glycolipid-dependent and lectin-driven transcytosis in mouse enterocytes.

Communications biology

Avec: Alena Ivashenka , Christian Wunder , Valerie Chambon , Roger Sandhoff , Richard Jennemann , Estelle Dransart , Katrina Podsypanina , Bérangère Lombard , Damarys Loew , Christophe Lamaze , Francoise Poirier , Hermann-Josef Gröne , Ludger Johannes , Massiullah Shafaq-Zadah

The prognostic value of galactosylceramide-sulfotransferase (Gal3ST1) in human renal cell carcinoma.

Scientific reports

Avec: Stefan Porubsky , Malin Nientiedt , Maximilian C Kriegmair , Jörn-Helge Heinrich Siemoneit , Roger Sandhoff , Richard Jennemann , Hendrik Borgmann , Timo Gaiser , Cleo-Aron Weis , Philipp Erben , Thomas Hielscher , Zoran V Popovic

Interaction between Bacteria and the Immune System for Cancer Immunotherapy: The α-GalCer Alliance.

International journal of molecular sciences

Avec: Arsenij Ustjanzew , Valentin Sencio , François Trottein , Jörg Faber , Roger Sandhoff , Claudia Paret

Bacterial immunogenic α-galactosylceramide identified in the murine large intestine: dependency on diet and inflammation.

Journal of lipid research

Avec: Johanna von Gerichten , Dominic Lamprecht , Lukáš Opálka , Daphnée Soulard , Christian Marsching , Robert Pilz , Valentin Sencio , Silke Herzer , Bruno Galy , Viola Nordström , Carsten Hopf , Hermann-Josef Gröne , François Trottein , Roger Sandhoff

TLR9-mediated dendritic cell activation uncovers mammalian ganglioside species with specific ceramide backbones that activate invariant natural killer T cells.

PLoS biology

Avec: Christophe Paget , Shenglou Deng , Daphnée Soulard , David A Priestman , Silvia Speca , Johanna von Gerichten , Anneliese O Speak , Ashish Saroha , Yael Pewzner-Jung , Anthony H Futerman , Thierry Mallevaey , Christelle Faveeuw , Xiaobo Gu , Frances M Platt , Roger Sandhoff , François Trottein

Gangliosides modulate insulin secretion by pancreatic beta cells under glucose stress.

Glycobiology

Avec: Richard Jennemann , Sylvia Kaden , Martina Volz , Viola Nordström , Silke Herzer , Roger Sandhoff , Hermann-Josef Gröne

Exploiting Gangliosides for the Therapy of Ewing's Sarcoma and H3K27M-Mutant Diffuse Midline Glioma.

Cancers

Avec: Arthur Wingerter , Khalifa El Malki , Roger Sandhoff , Larissa Seidmann , Daniel-Christoph Wagner , Nadine Lehmann , Nadine Vewinger , Katrin B M Frauenknecht , Clemens J Sommer , Frank Traub , Thomas Kindler , Alexandra Russo , Henrike Otto , André Lollert , Gundula Staatz , Lea Roth , Claudia Paret , Jörg Faber

Autosomal dominant lamellar ichthyosis due to a missense mutation in the gene NKPD1.

The Journal of investigative dermatology

Avec: Katalin Komlosi , Cristina Glocker , Hao-Hsiang Hsu-Rehder , Svenja Alter , Julia Kopp , Alrun Hotz , Andreas David Zimmer , Ingrid Hausser-Siller , Roger Sandhoff , Vinzenz Oji , Judith Fischer

A Clathrin light chain A reporter mouse for in vivo imaging of endocytosis.

PloS one

Avec: Elisabeth Grimm , Franciscus van der Hoeven , Donato Sardella , Katrin I Willig , Ulrike Engel , Nisha Veits , Robert Engel , Elisabetta Ada Cavalcanti-Adam , Felix Bestvater , Luca Bordoni , Richard Jennemann , Kai Schönig , Ina Maria Schiessl , Roger Sandhoff

Glucosylceramide Synthase Inhibitors Induce Ceramide Accumulation and Sensitize H3K27 Mutant Diffuse Midline Glioma to Irradiation.

International journal of molecular sciences

Avec: Khalifa El Malki , Pia Wehling , Francesca Alt , Roger Sandhoff , Sebastian Zahnreich , Arsenij Ustjanzew , Carolin Wilzius , Marc A Brockmann , Arthur Wingerter , Alexandra Russo , Olaf Beck , Clemens Sommer , Malte Ottenhausen , Katrin B M Frauenknecht , Claudia Paret , Jörg Faber

Réseau de co-auteurs

Richard Jennemann 9 collaborations

Claudia Paret 6 collaborations

Hermann-Josef Gröne 5 collaborations

Jörg Faber 5 collaborations

Christian Marsching 4 collaborations

Robert Pilz 4 collaborations

Arsenij Ustjanzew 4 collaborations

Khalifa El Malki 4 collaborations

Alexandra Russo 4 collaborations

Arthur Wingerter 4 collaborations

Silke Herzer 3 collaborations

Felix Bestvater 3 collaborations

Viola Nordström 3 collaborations

Johanna von Gerichten 3 collaborations

Alaa Madi 3 collaborations

Sicong Ma 3 collaborations

Jingxia Wu 3 collaborations

Kerstin Mohr 3 collaborations

Guoliang Cui 3 collaborations

Larissa Seidmann 3 collaborations

Katrin B M Frauenknecht 3 collaborations

François Trottein 3 collaborations

Aline Bayerle 2 collaborations

Mariona Rabionet 2 collaborations

Shaalee Dworski 2 collaborations

Mustafa A Kamani 2 collaborations

Chandramohan Chitraju 2 collaborations

Nina L Gluchowski 2 collaborations

Katlyn R Gabriel 2 collaborations

Jeffrey A Medin 2 collaborations

Martina Volz 2 collaborations

Karsten Richter 2 collaborations

Sylvia Kaden 2 collaborations

Johannes Müthing 2 collaborations

Christian Wunder 2 collaborations

Ludger Johannes 2 collaborations

Lukáš Opálka 2 collaborations

Elisabeth Grimm 2 collaborations

Judith Fischer 2 collaborations

Marvin Hering 2 collaborations

Alessa Mieg 2 collaborations

Gernot Poschet 2 collaborations

Yanan Ming 2 collaborations

Nina Weisshaar 2 collaborations

Thomas Hielscher 2 collaborations

Nicole Ziegler 2 collaborations

Malte Ottenhausen 2 collaborations

Clemens Sommer 2 collaborations

Nadine Lehmann 2 collaborations

Lea Roth 2 collaborations

Valentin Sencio 2 collaborations

Daphnée Soulard 2 collaborations

Thierry Levade 1 collaboration

Claudia Schmidt 1 collaboration

Pauline Bernard 1 collaboration

Melanie Pichery 1 collaboration

Abolfazl Asadi 1 collaboration

Philipp Ebel 1 collaboration

Menno Hoekstra 1 collaboration

Sabrina Dumas 1 collaboration

James M Ntambi 1 collaboration

Anders Jacobsson 1 collaboration

Klaus Willecke 1 collaboration

Nathalie Jonca 1 collaboration

Bhuvaneswari Nagarajan 1 collaboration

Alexander Harder 1 collaboration

Anna Japp 1 collaboration

Felix Häberlein 1 collaboration

Enrico Mingardo 1 collaboration

Henning Kleinert 1 collaboration

Öznur Yilmaz 1 collaboration

Angelika Zoons 1 collaboration

Birgit Rau 1 collaboration

Andrea Christ 1 collaboration

Ulrich Kubitscheck 1 collaboration

Britta Eiberger 1 collaboration

Matthias Eckhardt 1 collaboration

Dieter Hartmann 1 collaboration

Benjamin Odermatt 1 collaboration

Ivan Morace 1 collaboration

Giuseppina Federico 1 collaboration

Damir Krunic 1 collaboration

Ina Maria Schießl 1 collaboration

Adam Majcher 1 collaboration

Lionel Van Maldergem 1 collaboration

Silvia Mihalceanu 1 collaboration

Knut Schäkel 1 collaboration

Alexander Enk 1 collaboration

François Aubin 1 collaboration

Anne-Claire Bursztejn 1 collaboration

Elise Brischoux-Boucher 1 collaboration

Nora Knabe 1 collaboration

Diana Stichling 1 collaboration

Larissa Frank 1 collaboration

Jochen Utikal 1 collaboration

Viktor Umansky 1 collaboration

Xiu Luo 1 collaboration

Fuwei Shang 1 collaboration

Qiaozhen Shi 1 collaboration

Zhaolong Li 1 collaboration

Frank Schwarz 1 collaboration

Ferdinand Zettl 1 collaboration

Xin Yan 1 collaboration

Nora Ten Bosch 1 collaboration

Zhe Li 1 collaboration

Hans-Reimer Rodewald 1 collaboration

Nina Papavasiliou 1 collaboration

Xi Wang 1 collaboration

Pu Gao 1 collaboration

Lavinia Arseni 1 collaboration

Rakesh Sharma 1 collaboration

Norman Mack 1 collaboration

Deepthi Nagalla 1 collaboration

Sibylle Ohl 1 collaboration

Mahak Singhal 1 collaboration

Hellmut Augustin 1 collaboration

Christel Herold-Mende 1 collaboration

Björn Tews 1 collaboration

Peter Lichter 1 collaboration

Martina Seiffert 1 collaboration

Sara Ersali 1 collaboration

Franziska Ortmüller 1 collaboration

Angelina Bornas 1 collaboration

Pia Charlotte Wehling 1 collaboration

Adina Lepădatu 1 collaboration

Wilfried Roth 1 collaboration

Barbara Fliss 1 collaboration

Agnes Hotz-Wagenblatt 1 collaboration

Vincent Timmerman 1 collaboration

Nathalie Bonello-Palot 1 collaboration

Beate Schlotter-Weigel 1 collaboration

Michaela Auer-Grumbach 1 collaboration

Pavel Seeman 1 collaboration

Wolfgang N Löscher 1 collaboration

Markus Reindl 1 collaboration

Florian Weiss 1 collaboration

Eric Mah 1 collaboration

Tilo Schlimbach 1 collaboration

Rubí M-H Velasco Cárdenas 1 collaboration

Jonas Koeppel 1 collaboration

Florian Grünschläger 1 collaboration

Lisann Müller 1 collaboration

Maren Baumeister 1 collaboration

Britta Brügger 1 collaboration

Michael Schmitt 1 collaboration

Guido Wabnitz 1 collaboration

Yvonne Samstag 1 collaboration

Marina A Woeste 1 collaboration

Sina Stern 1 collaboration

Diana N Raju 1 collaboration

Elena Grahn 1 collaboration

Dominik Dittmann 1 collaboration

Katharina Gutbrod 1 collaboration

Peter Dörmann 1 collaboration

Jan N Hansen 1 collaboration

Sophie Schonauer 1 collaboration

Carina E Marx 1 collaboration

Hussein Hamzeh 1 collaboration

Heinz G Körschen 1 collaboration

Johannes M F G Aerts 1 collaboration

Wolfgang Bönigk 1 collaboration

Heike Endepols 1 collaboration

Matthias Geyer 1 collaboration

Thomas K Berger 1 collaboration

Frank Bradke 1 collaboration

Dagmar Wachten 1 collaboration

Konrad Sandhoff 1 collaboration

Annekathrin Silvia Nedwed 1 collaboration

Federico Marini 1 collaboration

M Margarida Souto-Carneiro 1 collaboration

Karel D Klika 1 collaboration

Mónica T Abreu 1 collaboration

André P Meyer 1 collaboration

Rainer Saffrich 1 collaboration

Franziska V Kraus 1 collaboration

Lars Tykocinski 1 collaboration

Volker Eckstein 1 collaboration

Lina Carvalho 1 collaboration

Mark Kriegsmann 1 collaboration

Thomas Giese 1 collaboration

Hanns-Martin Lorenz 1 collaboration

Rui A Carvalho 1 collaboration

Theun de Groot 1 collaboration

Lena K Ebert 1 collaboration

Birgitte Mønster Christensen 1 collaboration

Karolina Andralojc 1 collaboration

Lydie Cheval 1 collaboration

Alain Doucet 1 collaboration

Cungui Mao 1 collaboration

Ruben Baumgarten 1 collaboration

Benjamin E Low 1 collaboration

Michael V Wiles 1 collaboration

Peter M T Deen 1 collaboration

Ron Korstanje 1 collaboration

Marie Astrid Neu 1 collaboration

Sebastian Foersch 1 collaboration

Nora Backes 1 collaboration

Joerg Faber 1 collaboration

Alena Ivashenka 1 collaboration

Valerie Chambon 1 collaboration

Estelle Dransart 1 collaboration

Katrina Podsypanina 1 collaboration

Bérangère Lombard 1 collaboration

Damarys Loew 1 collaboration

Christophe Lamaze 1 collaboration

Francoise Poirier 1 collaboration

Massiullah Shafaq-Zadah 1 collaboration

Stefan Porubsky 1 collaboration

Malin Nientiedt 1 collaboration

Maximilian C Kriegmair 1 collaboration

Jörn-Helge Heinrich Siemoneit 1 collaboration

Hendrik Borgmann 1 collaboration

Timo Gaiser 1 collaboration

Cleo-Aron Weis 1 collaboration

Philipp Erben 1 collaboration

Zoran V Popovic 1 collaboration

Dominic Lamprecht 1 collaboration

Bruno Galy 1 collaboration

Carsten Hopf 1 collaboration

Christophe Paget 1 collaboration

Shenglou Deng 1 collaboration

David A Priestman 1 collaboration

Silvia Speca 1 collaboration

Anneliese O Speak 1 collaboration

Ashish Saroha 1 collaboration

Yael Pewzner-Jung 1 collaboration

Anthony H Futerman 1 collaboration

Thierry Mallevaey 1 collaboration

Christelle Faveeuw 1 collaboration

Xiaobo Gu 1 collaboration

Frances M Platt 1 collaboration

Daniel-Christoph Wagner 1 collaboration

Nadine Vewinger 1 collaboration

Clemens J Sommer 1 collaboration

Frank Traub 1 collaboration

Thomas Kindler 1 collaboration

Henrike Otto 1 collaboration

André Lollert 1 collaboration

Gundula Staatz 1 collaboration

Katalin Komlosi 1 collaboration

Cristina Glocker 1 collaboration

Hao-Hsiang Hsu-Rehder 1 collaboration

Svenja Alter 1 collaboration

Julia Kopp 1 collaboration

Alrun Hotz 1 collaboration

Andreas David Zimmer 1 collaboration

Ingrid Hausser-Siller 1 collaboration

Vinzenz Oji 1 collaboration

Franciscus van der Hoeven 1 collaboration

Donato Sardella 1 collaboration

Katrin I Willig 1 collaboration

Ulrike Engel 1 collaboration

Nisha Veits 1 collaboration

Robert Engel 1 collaboration

Elisabetta Ada Cavalcanti-Adam 1 collaboration

Luca Bordoni 1 collaboration

Kai Schönig 1 collaboration

Ina Maria Schiessl 1 collaboration

Pia Wehling 1 collaboration

Francesca Alt 1 collaboration

Sebastian Zahnreich 1 collaboration

Carolin Wilzius 1 collaboration

Marc A Brockmann 1 collaboration

Olaf Beck 1 collaboration