Endogenous levels of 1-O-acylceramides increase upon acidic ceramidase deficiency and decrease due to loss of Dgat1 in a tissue-dependent manner.

Animals Brain / metabolism Ceramides / metabolism Colon / metabolism Diacylglycerol O-Acyltransferase / metabolism Farber Lipogranulomatosis / metabolism Intestine, Small / metabolism Kidney / metabolism Lipid Metabolism Liver / metabolism Lung / metabolism Lymph Nodes / metabolism Male Mice, Inbred C57BL Myocardium / metabolism Spleen / metabolism Thymus Gland / metabolism
Acylceramides Acyltransferases Asah1 Brain Ceramides Dgat Dgat1 Dgat2 Farber disease Heart Intestine Kidney Liver Lung Mammalian Spleen Thymus Ugcg

Journal

Biochimica et biophysica acta. Molecular and cell biology of lipids
ISSN: 1879-2618
Titre abrégé: Biochim Biophys Acta Mol Cell Biol Lipids
Pays: Netherlands
ID NLM: 101731727

Informations de publication

Date de publication:
09 2020
Historique:
received: 17 01 2020
revised: 19 04 2020
accepted: 15 05 2020
pubmed: 1 6 2020
medline: 1 1 2021
entrez: 1 6 2020
Statut: ppublish

Résumé

Except for epidermis and liver, little is known about endogenous expression of 1-O-acylceramides (1-OACs) in mammalian tissue. Therefore, we screened several organs (brain, lung, liver, spleen, lymph nodes, heart, kidney, thymus, small intestine, and colon) from mice for the presence of 1-OACs by LC-MS

Identifiants

DOI: 10.1016/j.bbalip.2020.158741 PMID: 32474112
pubmed: 32474112
pii: S1388-1981(20)30133-5
doi: 10.1016/j.bbalip.2020.158741
pii:
doi:

Substances chimiques

Ceramides 0
Dgat1 protein, mouse EC 2.3.1.20
Diacylglycerol O-Acyltransferase EC 2.3.1.20

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

158741

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Aline Bayerle (A)

Lipid Pathobiochemistry Group, German Cancer Research Center, Heidelberg, Germany.

Christian Marsching (C)

Lipid Pathobiochemistry Group, German Cancer Research Center, Heidelberg, Germany; Center for Applied Research in Biomedical Mass Spectrometry (ABIMAS), Mannheim, Germany; Instrumental Analytics and Bioanalytics, Mannheim University of Applied Sciences, Mannheim, Germany; Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Mannheim, Germany.

Mariona Rabionet (M)

Lipid Pathobiochemistry Group, German Cancer Research Center, Heidelberg, Germany.

Shaalee Dworski (S)

Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada.

Mustafa A Kamani (MA)

University Health Network, Toronto, Canada.

Chandramohan Chitraju (C)

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.

Nina L Gluchowski (NL)

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA; Division of Gastroenterology and Nutrition, Boston Children's Hospital, Boston, MA, USA.

Katlyn R Gabriel (KR)

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Boston, MA, USA.

Silke Herzer (S)

Lipid Pathobiochemistry Group, German Cancer Research Center, Heidelberg, Germany.

Richard Jennemann (R)

Lipid Pathobiochemistry Group, German Cancer Research Center, Heidelberg, Germany.

Thierry Levade (T)

Laboratoire de Biochimie Métabolique, Institut Fédératif de Biologie, CHU Purpan, INSERM UMR1037 CRCT, Toulouse, France.

Jeffrey A Medin (JA)

Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada; University Health Network, Toronto, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Roger Sandhoff (R)

Lipid Pathobiochemistry Group, German Cancer Research Center, Heidelberg, Germany; Center for Applied Research in Biomedical Mass Spectrometry (ABIMAS), Mannheim, Germany. Electronic address: r.sandhoff@dkfz.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Endogenous levels of 1-O-acylceramides...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Endogenous levels of 1-O-acylceramides...
questionsmedicales.fr › Lipides › Lipides membranaires › Sphingolipides › Glycosphingolipides › Glycosphingolipides neutres › Céramides › Endogenous levels of 1-O-acylceramides...
questionsmedicales.fr › Système digestif › Tube digestif › Tube digestif inférieur › Gros intestin › Côlon › Endogenous levels of 1-O-acylceramides...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Acyltransferases › Diacylglycerol O-acyltransferase › Endogenous levels of 1-O-acylceramides...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Erreurs innées du métabolisme › Maladies lysosomiales › Maladies neurologiques de surcharge lysosomiale › Sphingolipidoses › Lipogranulomatose de Farber › Endogenous levels of 1-O-acylceramides...
questionsmedicales.fr › Système digestif › Tube digestif › Intestins › Intestin grêle › Endogenous levels of 1-O-acylceramides...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Endogenous levels of 1-O-acylceramides...
questionsmedicales.fr › Métabolisme › Métabolisme lipidique › Endogenous levels of 1-O-acylceramides...
questionsmedicales.fr › Système digestif › Foie › Endogenous levels of 1-O-acylceramides...
questionsmedicales.fr › Appareil respiratoire › Poumon › Endogenous levels of 1-O-acylceramides...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Noeuds lymphatiques › Endogenous levels of 1-O-acylceramides...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Endogenous levels of 1-O-acylceramides...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Myocarde › Endogenous levels of 1-O-acylceramides...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Rate › Endogenous levels of 1-O-acylceramides...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Thymus (glande) › Endogenous levels of 1-O-acylceramides...