Renal globotriaosylceramide facilitates tubular albumin absorption and its inhibition protects against acute kidney injury.
Acute Kidney Injury
/ chemically induced
Albumins
/ metabolism
Animals
Dioxanes
/ pharmacology
Disease Models, Animal
Galactosyltransferases
/ antagonists & inhibitors
Gentamicins
/ metabolism
Humans
Intravital Microscopy
Kidney Tubules, Proximal
/ drug effects
Low Density Lipoprotein Receptor-Related Protein-2
/ metabolism
Male
Mice
Mice, Knockout
Microscopy, Electron
Microscopy, Fluorescence, Multiphoton
Microvilli
/ drug effects
Myoglobin
/ metabolism
Pyrrolidines
/ pharmacology
Receptors, Cell Surface
/ metabolism
Renal Elimination
/ drug effects
Renal Reabsorption
/ drug effects
Trihexosylceramides
/ metabolism
acute kidney injury
endocytosis
gentamicin
globotriaosylceramide
rhabdomyolysis
Journal
Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
28
06
2018
revised:
01
02
2019
accepted:
07
02
2019
pubmed:
19
5
2019
medline:
2
10
2020
entrez:
19
5
2019
Statut:
ppublish
Résumé
To elucidate the physiologic function of renal globotriaosylceramide (Gb3/CD77), which up-to-date has been associated exclusively with Shiga toxin binding, we have analyzed renal function in Gb3-deficient mice. Gb3 synthase KO (Gb3S
Identifiants
pubmed: 31101366
pii: S0085-2538(19)30197-8
doi: 10.1016/j.kint.2019.02.010
pii:
doi:
Substances chimiques
(2-(2',3'-dihydrobenzo(1,4)dioxin-6'-yl)-2-hydroxy-1-pyrrolidin-1-ylmethylethyl)nonanoic acid amide
0
Albumins
0
Dioxanes
0
Gentamicins
0
Low Density Lipoprotein Receptor-Related Protein-2
0
Lrp2 protein, mouse
0
Myoglobin
0
Pyrrolidines
0
Receptors, Cell Surface
0
Trihexosylceramides
0
intrinsic factor-cobalamin receptor
0
globotriaosylceramide
71965-57-6
Galactosyltransferases
EC 2.4.1.-
UDP-galactose-lactosylceramide alpha 1-4-galactosyltransferase
EC 2.4.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
327-341Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.