Elastin-Specific Autoimmunity in Smokers With Thoracic Aortic Aneurysm and Dissection is Independent of Chronic Obstructive Pulmonary Disease.
Adult
Aged
Aortic Dissection
/ epidemiology
Aortic Aneurysm, Thoracic
/ epidemiology
Autoantibodies
/ immunology
Autoimmunity
CD4-Positive T-Lymphocytes
/ immunology
Case-Control Studies
Cigarette Smoking
/ immunology
Cross-Sectional Studies
Elastin
/ immunology
Ex-Smokers
Female
Forced Expiratory Volume
Humans
Interferon-gamma
/ immunology
Interleukin-1beta
/ immunology
Leukocyte Elastase
/ metabolism
Male
Matrix Metalloproteinase 12
/ metabolism
Matrix Metalloproteinase 9
/ metabolism
Middle Aged
Non-Smokers
Peptide Fragments
/ immunology
Pulmonary Disease, Chronic Obstructive
/ epidemiology
Smokers
Vital Capacity
aneurysm
immune system
immunology
inflammation
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
16 04 2019
16 04 2019
Historique:
entrez:
9
4
2019
pubmed:
9
4
2019
medline:
24
7
2020
Statut:
ppublish
Résumé
Background Thoracic aortic aneurysm ( TAA ) and dissection ( TAD ) are characterized by progressive disorganization of the aortic wall matrix, including elastin, a highly immunogenic molecule. Whether acquired autoimmune responses can be detected in TAA / TAD patients who are smokers is unknown. The objectives of this study were to determine whether TAA / TAD smokers have increased T-cell responses to human elastin fragments, and to determine whether autoimmune responses in TAA / TAD smokers are dependent on chronic obstructive pulmonary disease. Methods and Results In a cross-sectional study (N=86), we examined peripheral blood CD 4
Identifiants
pubmed: 30957625
doi: 10.1161/JAHA.118.011671
pmc: PMC6507218
doi:
Substances chimiques
Autoantibodies
0
IFNG protein, human
0
IL1B protein, human
0
Interleukin-1beta
0
Peptide Fragments
0
Interferon-gamma
82115-62-6
Elastin
9007-58-3
ELANE protein, human
EC 3.4.21.37
Leukocyte Elastase
EC 3.4.21.37
MMP9 protein, human
EC 3.4.24.35
Matrix Metalloproteinase 9
EC 3.4.24.35
MMP12 protein, human
EC 3.4.24.65
Matrix Metalloproteinase 12
EC 3.4.24.65
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e011671Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL110883
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268200900014C
Pays : United States
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