Brain functional alterations observed 4-weekly in major depressive disorder following antidepressant treatment.
Adult
Antidepressive Agents
/ pharmacology
Depressive Disorder, Major
/ drug therapy
Female
Hemodynamics
/ drug effects
Humans
Longitudinal Studies
Male
Oxyhemoglobins
/ metabolism
Prefrontal Cortex
/ blood supply
Psychiatric Status Rating Scales
Sertraline
/ pharmacology
Spectroscopy, Near-Infrared
Time Factors
Treatment Outcome
Young Adult
Antidepressant treatment
Depression
Longitudinal study
Near-infrared spectroscopy
Neuroimaging
Sertraline
Journal
Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073
Informations de publication
Date de publication:
01 06 2019
01 06 2019
Historique:
received:
17
12
2018
revised:
29
03
2019
accepted:
02
04
2019
pubmed:
9
4
2019
medline:
6
2
2020
entrez:
9
4
2019
Statut:
ppublish
Résumé
Major depressive disorder (MDD) is a heterogeneous condition. Identifying the brain responses to antidepressant treatment is of particular interest as these may represent potential neural networks related to treatment response, forming one aspect of the biological markers of MDD. Near-infrared spectroscopy (NIRS) is suitable for repeated measurements with short intervals because of its noninvasiveness, and can provide detailed time courses of functional alterations in prefrontal regions. We conducted a 12-week longitudinal study to explore prefrontal hemodynamic changes at 4-week intervals following sertraline treatment in 11 medication-naïve participants with MDD using 52-channel NIRS. While all participants achieved remission after treatment, intra-class correlation coefficient of oxygenated hemoglobin [oxy-Hb] values throughout the 12-week observation was moderate at the spatially and temporally contiguous cluster located in the left inferior frontal and temporal gyri. There was a significant negative correlation between mean [oxy-Hb] values in the significant cluster at 4 weeks and changes in Hamilton Rating Scale for Depression total score from 4 to 8 weeks (r = -0.73, P = 0.011) and from 4 to 12 weeks (r = -0.63, P = 0.039). Without healthy controls for comparison, we were unable to fully evaluate whether improvement of [oxy-Hb] activations after treatment in MDD reached normal levels or not. Our NIRS findings of detailed prefrontal hemodynamic alterations over short interval observations such as 4 weeks may have revealed potential trait marker for MDD and biological maker for predicting clinical response to sertraline treatment in MDD.
Sections du résumé
BACKGROUND
Major depressive disorder (MDD) is a heterogeneous condition. Identifying the brain responses to antidepressant treatment is of particular interest as these may represent potential neural networks related to treatment response, forming one aspect of the biological markers of MDD. Near-infrared spectroscopy (NIRS) is suitable for repeated measurements with short intervals because of its noninvasiveness, and can provide detailed time courses of functional alterations in prefrontal regions.
METHODS
We conducted a 12-week longitudinal study to explore prefrontal hemodynamic changes at 4-week intervals following sertraline treatment in 11 medication-naïve participants with MDD using 52-channel NIRS.
RESULTS
While all participants achieved remission after treatment, intra-class correlation coefficient of oxygenated hemoglobin [oxy-Hb] values throughout the 12-week observation was moderate at the spatially and temporally contiguous cluster located in the left inferior frontal and temporal gyri. There was a significant negative correlation between mean [oxy-Hb] values in the significant cluster at 4 weeks and changes in Hamilton Rating Scale for Depression total score from 4 to 8 weeks (r = -0.73, P = 0.011) and from 4 to 12 weeks (r = -0.63, P = 0.039).
LIMITATIONS
Without healthy controls for comparison, we were unable to fully evaluate whether improvement of [oxy-Hb] activations after treatment in MDD reached normal levels or not.
CONCLUSION
Our NIRS findings of detailed prefrontal hemodynamic alterations over short interval observations such as 4 weeks may have revealed potential trait marker for MDD and biological maker for predicting clinical response to sertraline treatment in MDD.
Identifiants
pubmed: 30959413
pii: S0165-0327(18)33176-8
doi: 10.1016/j.jad.2019.04.001
pii:
doi:
Substances chimiques
Antidepressive Agents
0
Oxyhemoglobins
0
Sertraline
QUC7NX6WMB
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
25-31Informations de copyright
Copyright © 2019. Published by Elsevier B.V.